DOI QR코드

DOI QR Code

Effects of Dietary Iodine and Selenium on the Activities of Blood Lymphocytes in Laying Hens

  • Song, Zhigang (State Key Laboratory for Animal Nutrition, College of Animal Science and Technology, China Agricultural University) ;
  • Guo, Yuming (State Key Laboratory for Animal Nutrition, College of Animal Science and Technology, China Agricultural University) ;
  • Yuan, Jianmin (State Key Laboratory for Animal Nutrition, College of Animal Science and Technology, China Agricultural University)
  • Received : 2005.02.15
  • Accepted : 2005.12.07
  • Published : 2006.05.01

Abstract

The effect of dietary iodine and selenium supplementation, alone or in combination, on peripheral blood lymphocyte function was determined in laying hens. Eight-hundred-and-sixty-four New-Loman laying hens were randomly allotted into 12 dietary treatments with different inclusion levels of iodine (0, 0.1 and 0.2 mg/kg), selenium (0, 0.05, 0.1 and 0.2 mg/kg) or their combinations for 24 weeks. The lipopolysaccharide (LPS) stimulation index, concanavalin A (ConA) stimulation index, peroxide enzyme activity and phagocytosis to neutral red particles were tested. There were significant differences in LPS stimulation index, ConA stimulation index, peroxide enzyme activity and phagocytosis to neutral red particles in different iodine or selenium supplementation levels (p<0.05). The highest iodine and selenium supplementation both resulted in highest LPS-/ConA-stimulation indices (p<0.05). However, when iodine was lower than 0.2 mg/kg, the additional effect of different levels of selenium did not always result in significant differences in these indices. The results indicated that iodine and selenium may affect immunity in laying hens and, when the iodine level in the laying hen is lower than 0.2 mg/kg, a selenium allowance higher than 0.1 mg/kg may be necessary to improve immunity.

Keywords

Laying Hens;Iodine;Selenium;Lymphocyte;Immune Function

References

  1. Cheng, T. SH. 2004a. Regulation of Zinc Amino Acid Complex on the Performance, Immune Responses and Antioxidant Capacity in Hens. Ph.D. Thesis, China Agricultural University
  2. Cheng, T. SH. and Y. M. Guo. 2004b. Effects of Salmonella Typhymurium Lipopolysaccharide Challenge on the Performance, Immune Responses and Zinc Metabolism of Laying Hens Supplemented with Two Zinc Sources. Asian-Aust. J. Anim. Sci. 17:1717-1724 https://doi.org/10.5713/ajas.2004.1717
  3. Contempre, B., J. E. Dumont and B. Ngo. 1991. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J. Clin. Endocrinol. Metab. 73:213-215 https://doi.org/10.1210/jcem-73-1-213
  4. DePalo, D., W. B. Kinlaw, C. Q. Zhao and D. L. St-Germain. 1994. Effect of selenium deficiency on type I 5'-deiodinase. J. Biol. Chem. 269(23):16223-16228
  5. Ernstrom, U. and B. Lasson. 1966. The influence of thyroxine on blood lymphocytes. Acta path. Microbial. Scand. 51:17
  6. Hotz, C. S., D. W. Fitzpatrick, K. D. Trick and M. R. L'Abbe. 1997. Dietary iodine and selenium interact to affect thyroid hormone metabolism in rats. J. Nutr. 127:1214-1218
  7. Orville, A. Levander and Philip, D. Whanger. 2000. Deliberations and evaluations of the approaches, endpoints and paradigms for selenium and iodine dietary recommendations. J. Nutr. 126:2427s-2434s
  8. Tizard, I. 1987. Veterinary Immunology: An introduction (3rd Ed.) W. B. Saunders, Philadelphia, P.A
  9. Wayne, Chris Hawkes and Nancy, L. Keim. 2003. Dietary selenium intake modulates thyroid hormone and energy metabolism in men. J. Nutr. 133:3443-3448
  10. Xia, Z. G., Y. M. Guo, S. Y. Chen and J. M. Yuan. 2003. Effects of dietary polyunsaturated fatty acids on antibody production and lymphocyte proliferation of laying hens. Asian-Aust. J. Anim. Sci. 16:1320-1325 https://doi.org/10.5713/ajas.2003.1320
  11. Arthur, J., R. Roderick, C. McKenzie and Geoffrey J. Beckett. 2003. Selenium in the immune system. J. Nutr. 133:1457s- 1459s
  12. Chen, Y. 1980. Effect of thyroxine on the immune response of mice in vivo and in vitro. Immunol. Comm. 9(3):269 https://doi.org/10.3109/08820138009065999
  13. Mu Li, Creswell J. Eastman and Steven C. Boyages. 1993. Iodine indeced lymphocytic thyroiditis in the BB/W rat: early and late immune phenomena. Autoimmunity 14:181-187 https://doi.org/10.3109/08916939309077364
  14. Davey, J. C., K. B. Becker and V. A. Galton. 1995. Cloning of a cDNA for the type II iodothyronine deiodinase. J. Biol. Chem. 270:26780-26786
  15. Fang, H. 2000. The study on the effects of iodine deficiency and iodine excess on the expression on thyroid TG and TPO mRNA in rats. Ph.D. Thesis, Tianjin Medical University, China
  16. Gupta, M. K., T. Chiang and S. D. Deodhar. 1983. Effect of thyroxine on immune response in C57B1/6J mice. Acta Endocr. Copenh. 103:76-80
  17. Follett, B. K. and C. Potts. 1990. Hypothyroidisan effects reproductive refractoriness and the seasonal oestrus period in Welsh Mountain ewes. J. Endocrinol. 127:103-109 https://doi.org/10.1677/joe.0.1270103
  18. Guo, Y. M. 1999. The necessity of selenium to normal thyroid hormone metabolism and the influence of selenium deficiency on the metabolism of sulphur-containing compounds. Ph.D. Thesis, China Agricultural University
  19. Lundell, G. and H. Blomgren. 1976. Lymphocyte populations in peripheral blood in hyperthyroid and euthyroid subjects. Clin. Experi. Iimmunol. 23:33-39
  20. Miller, J. K., E. W. Swanson, W. A. Lyke and W. F. Byrne. 1974. Effect of thyroid status on digestive tract fill and flow rate of undigested residues in cattle. J. Dairy Sci. 57:193-197 https://doi.org/10.3168/jds.S0022-0302(74)84859-9
  21. Ramauge, M., S. Paullud, A. Esfandiari, J. M. Gavaret and F. Courtin. 1996. Evidence that type III iodothyronine deiodinase in rat astrocyte is a selenoprotein. Endocrinol. 137:3021-3025 https://doi.org/10.1210/en.137.7.3021
  22. Fabris, N. 1973. Immunodepression in thyroid-deprived animals. Clin. Exper. Immunol. 15:601-611
  23. Schone, F., H. Ludke, A. Hennig and G. Jahreis. 1988. Copper and iodine in pig diets with high glucosinolate rapseed meal: II. Influence of iodine in pig diets with rapseed meal untreated or treated with copper ions on performance and thyroid hormone status of growing pigs. Anim. Feed Sci. Technol. 22:45-59 https://doi.org/10.1016/0377-8401(88)90073-9
  24. Liu, Y. 2004. Effects of $\beta$-1,3/1,6-glucan on performance and immune response of broilers. Ph.D. Thesis, China Agricultural University
  25. Shen, H. M., C. F. Yang and C. N. Ong. 1999. Sodium seleniteinduced oxidative stress and apoptosis in human hepatoma HepG(2) cells. Int. J. Cancer 81:820-828 https://doi.org/10.1002/(SICI)1097-0215(19990531)81:5<820::AID-IJC25>3.0.CO;2-F
  26. Philip, S., M. D. Schoenfeld and W. James. 1995. Suppression of cell-mediated immunity in hypothyroidism. Immunity and Hypothyroidism 88(3):347-349
  27. Ganong, W. F. 2001. Review of Medical Physiology, Twentieth Edition. New York: McGraw-Hill, Inc., pp. 307-321
  28. Paavonen, T. 1982. Enhancement of human B lymphocyte differentiation in vitro by thyroid hormone. Scand. J. Immunol. 15:211-215 https://doi.org/10.1111/j.1365-3083.1982.tb00640.x
  29. National Research Council. Nutrient Requirements of Poultry [M], Ninth Revised Edition. National Academy Press, 1994, Washington, DC
  30. Anita, S., P. S. Singha, K. S. Dhillon and Shashi Nayyar. 2004. Antioxidant Enzymes in Postpartum Anoestrus Buffaloes Supplemented with Vitamin E and Selenium. Asian-Aust. J. Anim. Sci. 17:608-611 https://doi.org/10.5713/ajas.2004.608
  31. Fabris, N., W. Pierpaoli and E. Sorkin. 1971. Hormones and the immunological capacity. IV. Restorative effect of developmental hormones or of lymphocytes on the immune deficiency syndrome of dwarf mouse. Clin. Exp. Immun. 9:227-240
  32. Wang, G. Y. and Z. B. Lin. 1997. Effects of 10-hydroxy-2- decenoic acid phagocytosis and cytokines production of peritoneal macrophage in vitro. Pharmachalogia Sinaica. 18(2):180-182
  33. Hayirli, A., N. Esenbuga, M. Macit, E. Lacin, M. Karaoglu, H. Karac and Yildiz. 2005. Nutrition Practice to Alleviate the Adverse Effects of Stress on Laying Performance, Metabolic Profile, and Egg Quality in Peak Producing Hens:1 The Humate Supplementation. Asian-Aust. J. Anim. Sci. 18:1310- 1319 https://doi.org/10.5713/ajas.2005.1310
  34. Schimizu, M. and Y. Schimizu. 1979. Lymphocyte proliferative response to viral antigen in pigs infected with transmissible gastroenteritis virus. Infect. Immun. 23:239
  35. Keast, D. and K. Taylor. 1982. The effect of tri-iodothyronine on the phytohaemagglutinin response of T lymphocytes. Clin. Experi. Immunol. 47:217-220
  36. Leonard, J. L. and T. J. Visser. 1986. "Biochemistry of deiodination", in (G. Hennemann), Thyroid Hormone Metabolism, Marcel Dekke, New York, NY, pp. 189-222
  37. Lin, Q. H. 1999. Lymphocytes transformation test. In: Methods of Immune Research (Ed. Q. H. Lin) Wuhan University Press. Wuhan, China. (in Chinese), pp. 188-190