Beams with web openings are an attractive system for multi-storey buildings where it is always desirable to have long spans. The openings in the web of steel beams enable building services to be integrated within the constructional depth of a floor, thus reducing the total floor depth. At the same time, the increased beam depth can give high bending moment capacity, thus allowing long spans. However, almost all of the research studies on web openings have been concentrated on beam behaviour at ambient temperature. In this paper, a preliminary numerical analysis using ABAQUS is conducted to develop a general understanding of the effect of the presence of web opening on the behaviour of steel beams at elevated temperatures. It is concluded that the presence of web openings will have substantial influence on the failure temperatures of axially unrestrained beams and the opening size at the critical position in the beam is the most important factor. For axially restrained beams, the effect of web openings on the beam's large deflection behaviour and catenary force is smaller and it is the maximum opening size that will affect the beam's response at very high temperatures. However, it is possible that catenary action develops in beams with web openings at temperatures much lower than the failure temperatures of the same beam without axial restraint that are often used as the basis of current design.