Effect of the Supply of Natural Water from Deep Sea Rock on the Immune Response and Antioxidant Activity in Rats

천연 암반 심해수 공급이 흰쥐의 면역반응 및 항산화 활성에 미치는 영향

  • 정수진 (국립한경대학교 낙농과학과) ;
  • 주은정 (국립한경대학교 낙농과학과) ;
  • 유지영 (국립한경대학교 낙농과학과) ;
  • 김윤경 (국립한경대학교 낙농과학과) ;
  • 조용진 (진해개발(주)) ;
  • 윤병선 (국립한경대학교 낙농과학과) ;
  • 조진국 (국립한경대학교 낙농과학과) ;
  • 남기택 (국립한경대학교 낙농과학과) ;
  • 황성구 (국립한경대학교 낙농과학과)
  • Published : 2006.04.30


This experiment was conducted to study the effects of the natural deep sea water, which contained approximately 2.3% salt, and various minerals of K, Mg, Ca, Na, Fe, Mn, Zn, Cu etc, on the immune response and antioxidant activity in rats. 24 Sprague Dawley rats were randomly allotted to a control group and 3 treatment groups. Control rats were supplied with filtered tap water, and each treatment group rats were supplied with 0.5% deep sea water, 1% deep sea water and Jijangsoo, respectively, which is upper clear water separated from sediment by the clay. Feed and water were provided ad libitum throughout the experiment that lasted for 4 weeks. The results showed that 1% deep sea water group showed the highest values in weight gain, feed intake, and feed efficiency than those of other groups. The levels of water intake of 1%- and 0.5%-deep sea water, and Jijangsoo group were 49.1%, 22.8%, and 40.5% higher than that of control group, respectively. The Jijangsoo group rats showed that perirenal and epididymal adipose tissue weights were decreased by 32% and 25%(p<0.05), respectively, when compared to control group rats. There were no remarkable differences of serum glucose concentration among all experimental groups. However, insulin concentration of experimental groups were remarkably increased in order of Jijangsoo (4.54), 1% deep sea water (3.70), 0.5% deep sea water (3.25)(p<0.05). B cell and T cell stimulation were increased about 44.7% and 207%, respectively, by 0.5% deep sea water in comparison with control (p<0.05). TBARS values of 0.5 % deep sea water group were significantly lower than that of control(p<0.05). Catalase and SOD activities of 0.5 % deep sea water group were 200% and 47% higher than that of control, respectively. From the results, it can be concluded that the supply of natural deep sea water can slightly improve the physiological activity which modulates immune response and antioxidant activity in rats.


Natural deep sea water;Immune response;Antioxidant activity;Lipid metabolism;Rat


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