Interactions of Vascular Risk Factors and Apolipoprotein E4 on Geriatric Depression

노년기 우울증에서 혈관성 위험인자와 아포지단백 E4의 상호작용

  • Park, Hye-Young (Department of Psychiatry, Chonnam National University Medical School) ;
  • Kim, Jae-Min (Department of Psychiatry, Chonnam National University Medical School) ;
  • Shin, Il-Seon (Department of Psychiatry, Chonnam National University Medical School) ;
  • Yang, Su-Jin (Department of Psychiatry, Chonnam National University Medical School) ;
  • Kim, Sung-Wan (Department of Psychiatry, Chonnam National University Medical School) ;
  • Kim, Seon-Young (Department of Psychiatry, Chonnam National University Medical School) ;
  • Shin, Hee-Young (Depression Clinical Research Center, Chonnam National University Hospital) ;
  • Yoon, Jin-Sang (Department of Psychiatry, Chonnam National University Medical School)
  • 박혜영 (전남대학교 의과대학 정신과학교실) ;
  • 김재민 (전남대학교 의과대학 정신과학교실) ;
  • 신일선 (전남대학교 의과대학 정신과학교실) ;
  • 양수진 (전남대학교 의과대학 정신과학교실) ;
  • 김성완 (전남대학교 의과대학 정신과학교실) ;
  • 김선영 (전남대학교 의과대학 정신과학교실) ;
  • 신희영 (전남대학교병원 우울증 임상연구 센터) ;
  • 윤진상 (전남대학교 의과대학 정신과학교실)
  • Published : 2006.05.31

Abstract

Objective : Associations of vascular risk/disease or apolipoprotein E ${\varepsilon}4$(APOE4) with geriatric depression has been unclear at a population level. This study aimed to evaluate whether there would be interactions of vascular risk/disease and APOE4 on depression in a Korean elderly population. Methods : 732 community residents aged 65 or over were assessed for depression(GMS), information on vascular risk/disease(reported stroke, transient ishemic attack, heart disease, hypertension, diabetes, smoking), examinations for vascular risk/disease(blood pressure, blood tests for glucose and lipid profiles, body size), APOE genotypes, demographic characteristics(age, gender, education), physical health, and cognitive function(MMSE). Results : Previous stroke and lower level of high density lipoprotein(HDL) cholesterol were significantly associated with geriatric depression independent of demographic characteristics, physical illnesses, and cognitive function. These associations were statistically significant only in those with APOE4, although the interaction terms didn't reach to statistical significance. Conclusion : Associations between vascular risk/disease and geriatric depression might be more prominent in those with APOE4. However further research would be needed to clarify this issue.