Biphasic Dynamic Kinetic Resolution of ρ,α-Dimethyl Benzyl Alcohol over Zeolite-Enzyme Catalysts

제올라이트-효소 촉매를 이용한 ρ,α-Dimethyl Benzyl Alcohol의 2상 동적 속도론적 광학분할

  • Cha, Yeon-Ju (Division of Materials and Chemical Engineering, Hanyang University) ;
  • Ko, Moon-Kyu (Department of Chemical and Biochemical Engineering, Konyang University) ;
  • Park, Yeung-Ho (Division of Materials and Chemical Engineering, Hanyang University)
  • 차연주 (한양대학교 재료화학공학부) ;
  • 고문규 (건양대학교 화학생명공학과) ;
  • 박융호 (한양대학교 재료화학공학부)
  • Received : 2006.10.12
  • Accepted : 2006.11.09
  • Published : 2006.12.10

Abstract

$\rho$, $\alpha$-dimethyl benzyl alcohol was resolved by the biphasic dynamic kinetic resolution (DKR). Acidic zeolite was used as a racemization catalyst while immobilized enzyme was employed for kinetic resolution. The effects of the process variables including nature of acyl donor, reaction temperature, substrate concentration, ratio of the two catalysts and stirring rate on the conversion and enantiomeric purity of the product were investigated. In DKR of $\rho$, $\alpha$-dimethyl benzyl alcohol, the product of 99% ee was obtained with a maximum yield of 88%. The high performance of the catalyst system was maintained in the condition of higher TON and under repeated use.

Keywords

biphasic dynamic kinetic resolution;$\rho$, $\alpha$-dimethyl benzyl alcohol;acidic zeolite;immobilized enzyme;process variables

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