Study on the Synthsis and Characteristics of Lipophilic Derivatives of β-Sitosterol

β-시토스테롤의 지용성 치환체의 합성 및 특성에 관한 연구

  • Chung, Dae-won (Department of Polymer Engineering, College of Engineering, Suwon University) ;
  • Cho, Young Tai (Department of Polymer Engineering, College of Engineering, Suwon University)
  • 정대원 (수원대학교 공과대학 신소재공학과) ;
  • 조영태 (수원대학교 공과대학 신소재공학과)
  • Received : 2006.03.09
  • Accepted : 2006.06.23
  • Published : 2006.08.10

Abstract

In the paper, lipophilic derivatives of $\beta$-sitosterol, which are known to have a potential to reduce blood cholesterol level, were synthesized by the esterification of $\beta$-sitosterol and fatty acids. When the esterification reactions using stearic acid, oleic acid or linoleic acid as fatty acids were carried out in the presence of an acidic catalyst, the reaction for unsaturated fatty acids such as oleic acid and linoleic acid afforded a significant amount of side products which may be produced by oxidation of unsaturated groups. On the other hand, esterification reactions in the presence of dehydrating agents and a basic catalyst gave pure products regardless of the nature of fatty acids. The solubilities of lipophilic derivatives of $\beta$-sitostero to organic solvents and edible oil were observed to increase as the degree of unsaturation of fatty acids increases.

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