Synthesis and Surface Activity of New Quaternary Ammonium Salts Prepared from 2-Chloromethyl-5-(2-Phenylthiazol-4-yl)-1,3,4-Oxadiazole

2-클로로메틸-5-(2-Phenylthiazol-4-yl)-1,3,4-옥사디아졸의 새로운 4급 암모늄염의 합성과 계면활성도

  • Bae, Sun Kun (School of Science and Technology, Kunsan National University) ;
  • Yeon, Young Heum (School of Science and Technology, Kunsan National University)
  • 배선건 (군산대학교 과학기술학부) ;
  • 연영흠 (군산대학교 과학기술학부)
  • Received : 2006.02.03
  • Accepted : 2006.04.26
  • Published : 2006.06.10

Abstract

New quaternary ammonium chlorides, [alkyldimethyl-[5-(2-phenylthiazol-4-yl]-1,3,4-oxadizol-2-ylmethyl]quaternary ammonium chlorides (ADOQACs): 6] were obtained with high yields by the reaction of compound 5 with N,N-dimethylalkyl amines in isopropyl alcohol. The structures and physical properties of the synthesized compounds were investigated and those surface-active properties were measured. The surface tension ($\gamma_{cmc}$) and the minimal inhibitory concentration (MIC) of compound 6 were found to be influenced by the number of alkyl chain carbon. Especially, compounds 6c and 6d exhibited high anti-bacterial activities and good surface-active properties.

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