Skin Anti-aging Effect of Forsythia viridissima L. Extract

연교추출물의 피부 항노화 효과

  • 김미진 ((주)사임당화장품 기술연구소) ;
  • 김자영 ((주)사임당화장품 기술연구소) ;
  • 정택규 ((주)사임당화장품 기술연구소) ;
  • 최상원 (대구가톨릭대학교 식품영양학과) ;
  • 윤경섭 ((주)사임당화장품 기술연구소)
  • Published : 2006.12.30

Abstract

Skin anti-aging effect of Forsythia viridissima L. extract was evaluated by using antioxidant assay, expression of type I procollagen, and UVA-induced matrix metalloproteinase-1 in human dermal fibroblasts. Matairesinol-rich Forsythia viridissima L. extract was showed the scavenging activity of radicals and reactive oxygen species with the $IC_{50}$ values of $4.50\;{\mu}m/ml$ against 1,1-diphenyl-2-picrylhydrazly radical and $542.43\;{mu}m/ml$ against superoxide radicals in the xanthine/xanthine oxidase system, respectively. The type I procollagen was increased 33.76% by treatment with matairesinol-rich Forsythia viridissima L. extract, and UVA-induced MMP-1 was reduced 35.78% in a dose dependent manner. In the human skin irritation test, 2% matairesinol-rich Forsythia viridissima L. extract did not show any adverse effect. Also, the clinical study indicated that a cream group treated with 0.2% matairesinol-rich Forsythia viridissima L. extract significantly reduced skin wrinkles, as compared with a non-treated cream group (p < 0.05). These results suggest that Forsythia viridissima L. extract may be useful as a potential source of functional anti-aging cosmetics.

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