Protective Effect of Pterocarpus santalinus on Galactosamine Induced Liver Damage

  • Dhanabal, S.P. (Department of Pharmacognosy and Pharmacology, JSS College of Pharmacy) ;
  • Syamala, G. (PSG College of Pharmacy) ;
  • Elango, K. (Department of Pharmacognosy and Pharmacology, JSS College of Pharmacy) ;
  • Suresh, B. (Department of Pharmacognosy and Pharmacology, JSS College of Pharmacy)
  • Published : 2006.03.01


The present study was carried out to investigate the hepatoprotective effect of the extract of Pterocarpus santalinus Linn on acute hepatotoxicity induced in Wistar albino rats by a single dose of Galactosamine (400 mg/kg). Suspensions of methanolic extract of heartwood of P. santalinus (200 and 400 mg/kg) in 0.3% Carboxy Methyl Cellulose (CMC) were administered p.o. to experimental animals and hepatoprotective activity was monitored by estimating aspartate amino transferase (ASAT, GOT), alanine amino transferase (ALAT, GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), total cholesterol (TC), triglycerides (TGL), albumin, total protein (TP) levels. The methanolic extract significantly reduced the elevation of serum transaminases and alterations of biochemical parameters induced by hepatotoxin, and alleviated the degree of liver damage. The results were supported by histopathological studies of liver samples showing regeneration of hepatocytes in treated animals. Silymarin (25 mg/kg), a known hepatoprotective drug was used for comparison. Based on the results obtained, it can be concluded that P. santalinus exerts hepatoprotective activity and may serve as a useful adjuvant in several clinical conditions associated with liver damage.



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