Analysis of Influenza Virus Isolates in Seoul during 2003-2004 Season

2003-2004 절기 서울지역의 인플루엔자 바이러스 분리 및 아형 분석

  • Hwang Young-Ok (Seoul Metropolitan Goverment Research Institute of Public Health and Enviroment) ;
  • Lee Jae-In (Seoul Metropolitan Goverment Research Institute of Public Health and Enviroment) ;
  • Seo Byung-tae (Seoul Metropolitan Goverment Research Institute of Public Health and Enviroment)
  • 황영옥 (서울특별시보건환경연구원) ;
  • 이재인 (서울특별시보건환경연구원) ;
  • 서병태 (서울특별시보건환경연구원)
  • Published : 2005.03.01

Abstract

Influenza is an important public health problem which occurs almost every winter in temperate climates and is often associated with increased rates of hospitalization and death. In 1999, our influenza surveillance was initiated with 4 voluntary sentinel physicians and the Public Health Center. During the 2003-2004 influenza season, 124 influenza viruses were isolated from 401 clinical specimens, which were collected from patients with Influenza-like illness(ILI) in Seoul. The case definition of ILI is a case with fever more than $38^{\circ}C$ and systemic symptoms; cough, or sore throat. ILI was the highest at the 20-49 age $group(23\%)$ and the rate of virus isolation was the highest at the 7-19 age $group(50\%)$. Among 124 influenza viruses, isolates 83 were identified as A/H3N2 type and others were subtyped as influenza B viruses in 2003-2004 season. Influenza viruses were collected $39.1\%$ at Nowon-Gu, $13.5\%$ Gangnam-Gu and Seocho-Gu etc. and the isolate rate of virus had the area difference; Yongsan-Gu $66.7\%$, Gangnam-gu $50.0\%$, Nowon-Gu $39.9\%$, Kangbuk-Gu $36.8\%$, Seocho-Gu $27.8\%$, Dongjak-Gu $21.2\%$. Out of 401 individuals, 160 was vaccinated $(40\%)$ and the vaccination rate was the highest at the 20-49 age $group(32\%)$. These findings may contribute to the recommondation of the influenza vaccine formulation and the development of influenza control measure.

Keywords

A/H3N2;ILI;influenza virus;subtype;type B

References

  1.  Crowley. 2001. An Introduction to Human Disease : Pathology and Pathophysiology. pp 723-726, Correlations, Jones & Bartlett
  2.  Khatchikian, D, M. Orlich, and R. Rott. 1989. Increased Viral pathogenicity after insertion of a 28S ribosomal RNA sequence into the hemagglutinin gene of an influenza Virus. Nature 340, 156-157 https://doi.org/10.1038/340156a0
  3. Stuart - Harris, C.N. Schild, and G. Oxford J.S. 1985. The epideniology of influenza. In Influenza : The Viruses and the Disease, pp. 118-256, 2nd ed. London Edward Arnold
  4. Webster, R.G., W.J. Bean, O.T. Gorman, T.M. Chamber, and Y. Kawaoka. 1992. Evolution and ecology of influenza A Viruses. Microbiol Rev. 56, 152-179
  5.  김지희, 김석현, 안정배, 이주연, 김도근. 1996. 인플루엔자 바이러스 국내분리주의 H항원 유전자의 염기서열 분석. 국립보건원보. 33, 170-175
  6.  국립보건원 2003. 사스관리지침. pp101-103
  7. Sang Heui Seo, E. Hoffmann, and R.G. Webster. 2002. Lethal H5N1 influenza viruses escape host anti-viral cytokine response. Nature medicine 8, 950-954 https://doi.org/10.1038/nm757
  8. World Health Organization. 2003. Management of severe acute respiratory syndrome (SARS). Revised 11. April. http://www. who.int/csr/sars/management/en
  9. Coiras, M.T., J.C. Aguilar, M.L. Garcia, I. Casas, and P. Perez-Brena. 2004. Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays. J. Med. Virol. 72(3), 484-495 https://doi.org/10.1002/jmv.20008
  10.  De Jong, J.C., E.C. Class, A.D. Osterhaus, R.G. Webster, and W.L. Lim. 1997. A pandemic warning?, Nature 389, 554-559
  11. Fedson, D. S. 1989. Prevention and control of influenza in institutional settings. Hosp. Pract. 24, 87-91
  12. Rachel, S. C., G. E. Smith, F. Warburton, T. Richard, M. White, and D. M. Fleming. 2002. Impact of NHS Direct on general practice consultations during the winter of 1999-2000 : analysis of routinely collected data, BMJ. 325, 1397-1398 https://doi.org/10.1136/bmj.325.7377.1397
  13.  국립보건원. 2002. 감염병발생정보. 제 13권 제9호 pp 143- 151
  14. Boni, M.F., J.R. Gog, V. Andreasen, and F.B. Christiansen. 2004. Influenza drift and epidemic size : the race between generating and escaping immunity. Theor. Popul. Biol. 65(2), 179-191 https://doi.org/10.1016/j.tpb.2003.10.002
  15. 이향, 김수진, 김영수. 2000. 서울지역에서 2000/2001 절 기 중 인플루엔자 바이러스 분리. 보건환경연구원보. 36, 26-31
  16.  황영옥, 서병태, 최병현. 2004. 서울지역의 인플루엔자 바이러스 분리 및 아형 분석에 의한 유행 예측도 조사. JVB, 34(1), 67-74
  17. Wiely, D.C. and T.T. Skehel. 1987. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu Rev Biochem. 56, 365-379 https://doi.org/10.1146/annurev.bi.56.070187.002053
  18. 고려대학교 신종전염병 연구소, 국립보건원. 2000. 제2차 인플루엔자 심포지움, (주)MS&C 서울
  19. Barker, W.H. and J.P. Mullooly. 1980. Impact of epidemic type A influenza in a defined adult population. Am. J. Epidemiol. 112, 798-811 https://doi.org/10.1093/oxfordjournals.aje.a113052
  20. 국립보건원 2003. 인플루엔자 소식지. Vol 3
  21.  Gleuzen, W.P., M. Decker, and D.M. Perrotta. 1987. Survey of underlying conditions of person hospitalized with acute respiratory disease during influenza epidemics in Houston. Am. Rev. Respir. Dis. 136, 550-555 https://doi.org/10.1164/ajrccm/136.3.550
  22.  국립보건원. 2000. 전염병예방법 개정에 따른 전염병보고 및 관리지침
  23. Weigl, J.A., W. Puppe, and H.J. Schmitt. 2004. Variables explaining the duration of hospitalization in children under two years of age admitted with acute airway infection : Does respiratory syncytial virus have a direct impact?, Klin Padiatr. 1, 7-15