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Correlation between Serum Leptin Levels and BMI in Adults Residing in Pohang, Korea

  • Published : 2005.03.01

Abstract

Leptin is a small polypeptide hormone secreted primarily by adipocytes. Leptin regulates energy balance by decreasing food intake and increasing energy expenditure. This study investigated the relationships between serum leptin levels and BMI (body mass index) in 49 adults in Pohang, Korea. The subjects were 25 males and 24 females, aged 21 to 64 years attending an outpatient clinic at Handong University Sunlin Presbyterian Hospital. Values are given +/- the standard error of the mean. Our study shows that the serum leptin levels in these subjects were positively correlated with BMI. The leptin levels were higher in females (2.39+/-1.82 ng/mL) than in males (0.43+/-0.455ng/mL), although lower than previously reported. We therefore compared the serum leptin levels from the male Korean subjects (BMI 24.3+/-0.74㎏/㎡) with serum from six British males with a similar BMI (23.4+/-1.48㎏/㎡). The serum leptin concentrations (1.76+/-0.76 ng/mL) were lower than that of plasma (4.28+/-1.66 ng/mL) in the British subjects. The serum leptin in the British subjects (1.76+/-0.76ng/mL) was higher than that in the Koreans. There was no correlation between leptin levels and BMI in either male (slope 0.018 ± 0.036, p=0.624) or female (slope 0.382±0.433, p=0.417) type 2 diabetic patients in Pohang, Korea. Taken together, our study shows that the serum leptin level in Koreans varies with the BMI, but is lower than that of BMI-matched British subjects.

References

  1. Lee TH, Kim SM, Lee DJ, Kim YS. 2000. Assessment of anthropometric indices of obesity in Korea. Korean J Obesity Studies 9: 276-282
  2. Ginsberg HN. 2000. Insulin resistance and cardiovascular disease. J Clin Invest 106: 453-458 https://doi.org/10.1172/JCI10762
  3. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432 https://doi.org/10.1038/372425a0
  4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549 https://doi.org/10.1126/science.7624778
  5. Haalas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546 https://doi.org/10.1126/science.7624777
  6. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. 1995. Effects of the obese gene product on body weight regulation in oblob mice. Science 269: 540-543 https://doi.org/10.1126/science.7624776
  7. Haffiner SM, Gingerich RL, Miettinen H, Stern MP. 1996. Leptin concentrations in relations to overall adiposity and regional body fat distribution in Mexican Americans. Int J Obes Relat Metab Disord 20: 904-908
  8. Ruhl CE, Everhart JE. 2001. Leptin concentrations in the United States: relations with demographic and anthropometric measures. Am J Clin Nutr 74: 295-301
  9. Hardie L, Trayhurn P, Abramovich D, Fowler P. 1997. Circulatingeptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol 47: 101-106 https://doi.org/10.1046/j.1365-2265.1997.2441017.x
  10. Donahue RP, Zimmet P, Bean JA, Decourten M, DeCarlo Donahue RA, Collier G, Goldberg RB, Prineas RJ, Skyler J, Schneiderman N. 1999. Cigarrete smoking, alcohol use, and physical activity, in relation to serum leptin levels in a multiethnic population: the Miami Community Health Study. Am J Epidemiol 9: 108-114 https://doi.org/10.1016/S1047-2797(98)00037-4
  11. Lonnqvist F, Arner P, Nordfors L, Schalling M. 1995. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med 1: 950-953 https://doi.org/10.1038/nm0995-950
  12. Gottschling-Zeller H, Birgel M, Scriba D, Blum WF, Hauner H. 1999. Depot-specific release of leptin from subcutaneous and omental adipocytes in suspension culture: effect of tumor necrosis factor- $\alpha$ and transforming growth factor-$\beta$1. Eur J Endocrinol 141: 436-442 https://doi.org/10.1530/eje.0.1410436
  13. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, Heinze E, Teller W, Hauner H. 1997. The contribution of androgen to the gender difference in leptin production on obese children and adolescents. J Clinical Investigation 100: 808-813 https://doi.org/10.1172/JCI119595
  14. Blum WF, Juul A. 1997. Reference ranges of serum leptin levels according to body mass index, gender, and developmental stage. In Leptin the voice of adipose tissue. Blum WF, Kiess W, Rascher WJA, eds. Thieme, Stuttgart/Barth, Leipzig, Heidelberg. p 318-326
  15. Wagner DR, Heyward VH. 2000. Measures of body composition in blacks and whites: a comparative review. Am J Clin Nutr 71: 1392-402
  16. Shim DJ, Kim SH, Kim YS, Choi YS, Jeong US, Lee HY, Choi HY, Kim JY, Lee SJ. 1999. Serum leptin concentration in diabetic and nondiabetic Koreans. Korean J Obesity Studies 8: 102-108
  17. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. 1995. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1: 1311-1314 https://doi.org/10.1038/nm1295-1311
  18. Considine RV, Sinha MK, Heiman ML, Aidas K, Thomas WS, Mark RN, Joanna PO, Cheryl CM, Linda JM, Thomas LB, Jose FC. 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295 https://doi.org/10.1056/NEJM199602013340503
  19. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, Lubina JA, Patane J, Self B, Hunt P, McCamish M. 1995. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282: 1568-1575 https://doi.org/10.1001/jama.282.16.1568