Antiobesity Effect of Major Korean Spices (Red Pepper Powder, Garlic and Ginger) in Rats Fed High Fat Diet

  • Yoon, Ji-Young (Department of Food Science and Nutrition, Pusan National University) ;
  • Jung, Keun-Ok (Department of Food Science and Nutrition, Pusan National University) ;
  • Kil, Jeung-Ha (Department of Food Science and Nutrition, Pusan National University) ;
  • Park, Kun-Young (Department of Food Science and Nutrition, Pusan National University)
  • Published : 2005.03.01


Commonly used spices in Korean cooking (red pepper powder, garlic, ginger) were evaluated for anti-obesity properties and effects on triglyceride (TG) and cholesterol in blood and adipose tissues in rats fed a high fat (20%) diet. SD rats were raised for four weeks on either a normal diet (ND, based on the AIN-93M diet), high fat diet (HFD, supplemented with 16% lard oil in the ND), or diets containing 5% red pepper powder (RPP), garlic or ginger. These spices significantly decreased weight gain compared to HFD, but garlic and ginger showed a greater effect on reducing weight gain than RPP. The weights of liver and epididymal and perirenal fat pads in garlic and ginger diet groups were lower than those of the HFD groups (p < 0.05). The garlic and ginger also decreased triglyceride and cholesterol contents in liver and epididymal and perirenal fat pad, reversing the higher levels seen in HFD. RPP, garlic and ginger supplemented diets were effective in lowering serum triglyceride and cholesterol levels (p< 0.05). These results indicated that garlic and ginger more effectively suppressed the effects of HFD on body fat gain and lipid values of adipose tissues and serum than RPP.


  1. Grundy SH. 1998. Muti-fratorial causation of obesity: implication for prevention. Am J Cli Nutr 67 (Suppl): 563s-572s
  2. Park HS. 2001. The approach to obesity and medical therapy at primary medical examination. Arch Family Med 22: 447-458
  3. Lim K, Yoshiok M, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M, Suzuki M. 1997. Dietary red pepper ingestion increases cabohydrate oxidation at rest and during exercise in runners. Med Sci Sports Exerc 29: 355-361
  4. Choi SM, Jeon YS, Rhee SH, Park KY. 2002. Red pepper powder and kimchi reduce body weight and blood and tissue lipids in rats fed a high fat diet. Nutraceut Food 7: 162-167
  5. Oi Y, Kawada T, Shishido C, Wada K, Kominato Y, Nishimura S, Ariga T, Iwai K. 1999. Ally-containing sulfides in garlic increase uncoupling content in brown adipose tissue, and noradrenaline and adrenaline secretion in rats. J Nutr 129: 336-342
  6. Yeh YY, Yeh SM. 1994. Garlic reduces plasma lipids by inhibiting hepatic and triacylglycerol synthesis. Lipids 29: 189-193
  7. Sheo HJ. 1999. Effects of garlic on the blood lipid and other serum components in rats. J Korean Soc Food Sc Nutr 28: 1139-1148
  8. Srivastava KC, Tyagi OD. 1993. Effects of garlic-derived principles (ajoene) on aggregation and arachinodic acid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids 49: 587-595
  9. Legnani C, Frascaro M, Guazzaloca G, Ludovici S, Cesarano G, Coccheri S. 1993. Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healty subject. Arzneimittelforschung 43: 119-122
  10. McMahon FG, Vargas R. 1993. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 13: 406-407
  11. Chang MW, Johnson MA. 1980. Effects of garlic on carbohydrate metabolism and lipid synthesis in rats. J Nutr 110: 931-936
  12. Suekawa M, Ishige A, Yusas K, Sudo K, Aburada M, Hosoya E. 1984. Pharmacological studies on ginger. 1. Pharmacological actions of pungent constituents, (6)-gin-gerol and (6)-shogaol. J Pharmacobiol Dyn 7: 836-848
  13. Bhandari U, Sharma JN, Zafar R. 1998. The protective action of ginger (Zinger officinale) extract infed rabbits. J Ethnopharmacology 61: 167-171
  14. Shin JH, Lee SJ, Sung NJ. 2002. Effects of Zinger mioga, Zinger mioga Root and Zinger officiale on the lipid concentration hyperlipidemic rats. J Korean Soc Food Sci Nutr 31: 679-684
  15. Bordia A, Verma SK, Srivastava KC. 1997. Effect of ginger (Zingiber officinale Rose.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 56: 379-384
  16. Reeves PG. 1997. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr 127: 838S-841S
  17. Folch J, Less M, Sbanestanley GH. 1975. A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem 226: 497-499
  18. Rhee SH, Kong KR, Jung KO, Park KY. 2003. Decreasing effect of kochujang on body weight and lipid levels of adipose tissues and serum in rats fed a high-fat diet. J Korean Soc Food Sci Nutr 32: 882-886
  19. Do MS, Hong SE, Ha JH, Choi SM, Ahn IS, Yoon JY, Park KY. 2004. Increased lipolytic activity by high-pun-gency red pepper extract (var. Chungyang) in rat adipocytes in vitro. J Food Sci Nutr 9: 34-38
  20. Kawada T, Hagihara KI, Iwai K. 1986. Effect of capsaicine on lipid metabolism in rats fed a high fat diet. J Nutr 116: 1272-1278
  21. Sambaiah K, Satyanrayana MN. 1982. Influence of red pepper and capsaicin on body composition and lipogenesis in rats. J Biosci 4: 425-430
  22. Choi SM, Jeon YS, Park KY. 2000. Comparison of quality of red pepper powders produced in Korea. Korean J Food Sci Technol 32: 1251-1257
  23. Sheo HJ. 2000. Toxic effects of the megadose garlic juice in the rats. J Korean Soc Food Sci Nutr 29: 485-492
  24. Kwon MJ, Song YS, Choi MS, Song YO. 2003. Red pepper attenutes cholesteryl ester transfer protein activity and atherosclerosis in chilesterol-fed rabbits. Elsevier Sci BV 332: 37-44
  25. Kawada T, Watanabe T, Takashi T, Tanaka T, Iwai K. 1986. Effect of capsaicin-induced beta-adrenergic action on oxygen consumption, the respiratory qutotient, and secondary strate utilization. Proc Soc Exp Biol Med 183: 250-2563
  26. Focke M, Feld A, Lichtenthaler K. 1990. Allicin, a occurring antibiotic from garlic, specially inhibits synthesis. Federation of European Bioche Soc Letters 261: 106-108
  27. Srinivassan K, Sambiaiah K. 1980. Hypocholesterolemic effect of red pepper and capsaicin. Indian J Exp Biol 18: 898-899
  28. Srinivassan K, Sambiaiah K. 1991. The effect spices on cholesterol 1 alpa-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int J Vitam Nutr Res 61: 364-369
  29. Yoshioka M, St-Pierre S, Suzuki M, Tremblay A. 1998. Effects of red pepper added to high-fat and high-car-bohydrate meals on energy metabolism and secondarystrate utilization in Japanese women. Br J Nutr 80: 503-510

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