A Case of Secondary Hypoadrenocorticism in a Dog

이차성 부신겉질저하증 1례

  • Bae Bo kyoung (College of Veterinary Medicine, Seoul National University) ;
  • Seo Kyoung won (College of Veterinary Medicine, Seoul National University) ;
  • Yoon Hwa young (College of Veterinary Medicine, Seoul National University) ;
  • Lee Chang woo (College of Veterinary Medicine, Seoul National University)
  • 배보경 (서울대학교 수의과대학) ;
  • 서경원 (서울대학교 수의과대학) ;
  • 윤화영 (서울대학교 수의과대학) ;
  • 이창우 (서울대학교 수의과대학)
  • Published : 2005.03.01


A 9-year old female Shih Tzu dog was presented to the Veterinary Medical Teaching Hospital of Seoul National University with a history of chronic intermittent anorexia and vomiting of 4-year duration. She visited 3 years ago with the same clinical signs but has not been treated regularly due to waxing-waning course. On the physical examination, no specific findings were found. CBC, serum chemistry, radiography, ACTH stimulation test, evaluation of serum T4 and TSH concentration were performed. Hypoadrenocorticism was diagnosed with the ACTH stimulation test. And then, secondary hypoadrenocorticism was diagnosed with ACTH stimulation test, pre-ACTH aldosterone concentration, endogenous ACTH concentration. As electrolyte concentrations were normal, glucocorticoid (0.15 mg/kg bid PO) alone was administered. She has recovered from the clinical signs and has been doing well. It is suggested that the differentiation of secondary hypoadrenocorticism from primary hypoadrenocorticism is important as the secondary hypoadrenocorticism occurs rarely and the symptoms are non-specific with normal electrolyte concentrations.


  1. Feldman EC, Nelson RW. Hypoadrenocorticism. In: Canine and feline endocrinology and reproduction, 3rd ed. St. Louis: Saunders. 2004: 394-439
  2. Hiroi Na. A trial of intranasal ACTH(1-24) administration to a patient with isolated ACTH deficiency. Med Sci Monit 2004: 10: CS9-13
  3. Herrtage ME. Hypoadrenocorticism. In: Textbook of veterinary internal medicine, 6th ed. Philadelphia: WB Saunders. 2005: 1612-1621
  4. Kintzer PP. Treatment and Long-Term Follow-up of 205 Dogs with Hypoadrenocorticism. J Vet Int Med 1997; 11: 43-49 https://doi.org/10.1111/j.1939-1676.1997.tb00072.x
  5. Kintzer PP, Peterson Me. Primary and secondary canine hypoadrenocorticism. Vet Clin North Am Small Anim Pract 1997; 27: 349-357
  6. Peterson ME. Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism: 225 cases(1979-1993). J Amer Vet Med Assoc 1996; 208:85-91
  7. Reusch CE. Hypoadrenocorticism. In: Textbook of veterinary internal medicine, 5th ed. St. Louise: Elservier Saunders. 2000: 1488-1499
  8. Torrance AG. Mooney CT. Hypoadrenocorticism. In BSAVA Manual of Small Animal Endocrinology, 2nd ed. Cheltenham: BSAVA. 1998: 75-82