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Effect of Recombinant Bovine Somatotropin Injections on Deer Stag Plasma Insulin-like Growth Factor-I Profiles

rBST 투여가 숫사슴의 혈액 내 IGF-I 함량에 미치는 영향

  • Shin, H.T. (Department of Food Biotechnology, Sungkyunkwan University) ;
  • Cui, S.H. (Department of Food Biotechnology, Sungkyunkwan University) ;
  • Chung, K.W. (Department of Food Biotechnology, Sungkyunkwan University) ;
  • Ahn, J.N. (Department of Food Biotechnology, Sungkyunkwan University) ;
  • Baig, S.Y. (Department of Food Biotechnology, Sungkyunkwan University)
  • 신형태 (성균관대학교 생명공학부 식품생명공학과) ;
  • 최송환 (성균관대학교 생명공학부 식품생명공학과) ;
  • 정기환 (성균관대학교 생명공학부 식품생명공학과) ;
  • 안재남 (성균관대학교 생명공학부 식품생명공학과) ;
  • 백순용 (성균관대학교 생명공학부 식품생명공학과)
  • Published : 2005.06.30

Abstract

This study was conducted to elucidate the influence of recombinant bovine somatotropin (rBST) on the plasma IGF-I profiles in deer stags. Slow release rBST (250mg each) preparations were injected subcutaneously during the antler's non-growing period and growing period. It was observed that significant increases in the plasma IGF-I concentrations were occurred right after injections of the rBST irrespective of antler's non-growing period or growing period. When the rBST preparations were injected two times with one week interval during the antler's non-growing period, the mean level of IGF-I was found to be 2,920.7ng I mL, indicating that the IGF-I concentration increased up to 8.4-folds compared with a control. After two weeks from second shot, however, the IGF-I levels decreased to the level of the control. Similar results were also obtained with both a Sika and a Red deer during the antler's growing period. Increases in the IGF-I level of up to 5.6-folds with the Sika deer and 4.3-folds with the Red deer were found. Based on the present study, it is likely that the rBST may be used as a possible candidate for an antler's growth stimulating agent.

Keywords

Sika deer;Red deer;Antler;rBST;IGF-I

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