Seasonal Distribution of T Serotyping and emm Genotyping of Group A Streptococci Obtained from Children with Streptococcal Infections in Masan, Korea, 2003~2004

2003~2004년 경남 마산 지역에서 분리된 A군 연쇄구균의 T 혈청형과 emm 유전자형의 계절별 분포

  • Jeon, Ho-Sang (Department of Pediatrics, College of Medicine, Kyunghee University) ;
  • Park, Hwa-Jin (Department of Pediatrics, College of Medicine, Kyunghee University) ;
  • Lee, Hee-Joo (Department of Laboratory Medicine, College of Medicine, Kyunghee University) ;
  • Ma, Sang-Hyuk (Department of Pediatrics, Fatima General Hospital) ;
  • Cha, Sung-Ho (Department of Pediatrics, College of Medicine, Kyunghee University)
  • 전호상 (경희대학교 의과대학 소아과학교실) ;
  • 박화진 (경희대학교 의과대학 소아과학교실) ;
  • 이희주 (경희대학교 의과대학 진단검사의학교실) ;
  • 마상혁 (창원파티마병원 소아과) ;
  • 차성호 (경희대학교 의과대학 소아과학교실)
  • Published : 2005.05.31

Abstract

Purpose : The aim of this study is to know seasonal distribution of group A streptococci obtained from one center using emm genotyping and T serotyping in Masan from 2003 through 2004. Methods : Among children who visited the Changwon Fatima Hospital at Masan, Korea from June 2003 through February 2004, 100 patients who had clinical findings of acute pharyngitis, scarlet fever, and cellulitis were confirmed as GAS by culture, and were enrolled in our study. All obtained GAS were sent to the WHO Collaborative Center for Reference and Research on Streptococci, University of Minnesota, Minneapolis for T serotyping and emm genotyping. We classified these results again according to seasonal and disease's entities. Results : 19 different T serotypes was typed. T4(27.5%), T1(17.6%), T6(13.7%), and T12(13.7%) serotypes were relatively common in summer, while T4(28.3%), T12(15.2%), and T12/B3264(8.7%) were common in winter. T4 and T12 were persistent all year around. Distribution of T serotypes in 89 patients with pharyngotonsillitis were T4(26.7%), T12(14.0%), T1(12.8%), and T6(11.6%) in order of frequency. 15 different emm genotypes was typed. The number of emm 1, emm 6, emm 9, and emm 44 genotypes decreased or disappeared in winter, and the number of emm 3, emm 12, and emm 89 genotypes increased or reappeared in winter. Conclusion : Because T serotyping and emm genotyping are useful tools for evaluating epidemiology and pathogenesis of group A streptococci, we should monitor these strains every year, and should serotype and genotype GAS obtained from the invasive streptococcal infections.