Adiponectin Induces Growth Arrest and Apoptosis of MDA-MB­231 Breast Cancer Cell

  • Kang Jee Hyun (Department of Family Medicine, College of Medicine, Konyang University) ;
  • Lee Yoon Young (Department of Family Medicine, College of Medicine, Korea University) ;
  • Yu Byung Yeon (Department of Family Medicine, College of Medicine, Konyang University) ;
  • Yang Beom-Seok (Biomedical Center, KIST) ;
  • Cho Kyung-Hwan (Department of Family Medicine, College of Medicine, Korea University) ;
  • Yoon Do Kyoung (Department of Family Medicine, College of Medicine, Korea University) ;
  • Roh Yong Kyun (Department of Family Medicine, College of Medicine, Hallym University)
  • Published : 2005.11.01

Abstract

Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.

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