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Zirconium(IV) Chloride - Catalysed Reaction of Indoles: An Expeditious Synthesis of Bis(indolyl)methanes

  • Nagawade, Rahul R. (Division of Medicinal Chemistry - New Drug Discovery, Wockhardt Research Centre) ;
  • Shinde, Devanand B. (Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University)
  • Published : 2005.12.20

Abstract

Zirconium(IV) chloride is found to be an efficient catalyst for the electrophilic addition reaction of indole with aldehydes/ketones to afford the corresponding bis(indolyl methanes in good yields. The remarkable features of this new procedure are high conversions, shorter reaction times, cleaner reaction profiles and simple experimental and work-up procedures.

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