Effect of Tea Catechin, EGCG (Epigallocatechin Gallate) on Killing of Oral Bacteria

차 카테킨 EGCG (Epigallocatechin Gallate)의 구강세균에 대한 살균효과

  • Yu Mi-Ok (Department of Life Science, Soonchun­hyang University) ;
  • Chun Jae-Woo (Department of Life Science, Soonchun­hyang University) ;
  • Oh Kye-Heon (Department of Life Science, Soonchun­hyang University)
  • 유미옥 (순천향대학교 자연과학대학 생명과학부) ;
  • 천재우 (순천향대학교 자연과학대학 생명과학부) ;
  • 오계헌 (순천향대학교 자연과학대학 생명과학부)
  • Published : 2004.12.01

Abstract

The purpose of this work was to investigate the effect oftea catechin, epigallocatechin gallate (EGCG) on killing of oral bacteria. The antibacterial activity of 2.5 mg/ml and 5.0 mg/ml EGCG was investigated for target bacteria of which initial cell number was approximately adjusted to $10^{7}ml$. The antibacterial activity of EGCG was proportional to the concentration according to colony-forming unit(CFU) of target bacteria enumerating on selective and complex media. Streptococcus mutans and Streptococcus sobrinus at 5mg/ml EGCG were completely killed within 8 hrs. Lactobacillus plantarum and Lactobacillus acidophilus were also killed within 2 hrs and 4 hrs under the same conditions, respectively. Oral bacteria at 2.5 mg/ml EGCG were completely killed within 10 hr. Colony numvers of S. mitis and S. salivarius treated with 2.5 mg/ml EGCG were decreased on MS solid media and no colony was observed on the media within 12 hrs. In consequence, EGCG would be a natural and effective compound that kill oral bacteria being caused of bad breath, plaque and gingivitis, and for preventing and treating dental caries.

Keywords

EGCG;oral bacteria;tea catechin

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