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Anti-Stress Effects of Ginseng in Immobilization-Stressed Rats

  • Choi, Eun-Ha (Department of Food and Nutritional Science, Ewha Womans University) ;
  • Lee, Hyun-Jung (Department of Food and Nutritional Science, Ewha Womans University) ;
  • Kim, Cheol-Jin (Korea Food Research Institute) ;
  • Kim, Jong-Tae (Korea Food Research Institute) ;
  • Kwun, In-Sook (Department of Food Science and Nutrition, Andong National University) ;
  • Kim, Yang-Ha (Department of Food and Nutritional Science, Ewha Womans University)
  • 발행 : 2004.09.01

초록

Stress is a global menace exacerbated by the advancement of industrialization. Failure of stress management is to a breakdown of the psychological and physiological protection mechanisms against stress. The aim of present study was to investigate the anti-stress potential of ginseng against immobilization stress. Male Sprague-Dawley rats (n=24) were divided into three groups; (i) control, (ii) immobilization stress (2hr daily, for 2 weeks), and (iii) immobilization stress (2 hr daily, for 2 weeks) plus oral administration of ginseng (200 mg/kg BW Id). Immobilization stress resulted in a significant inhibition of body weight gain by 45 % and a significant decrease in the tissue weights of thymus and spleen (p < 0.05). The concentrations of blood GOT and GPT were significantly increased in the immobilization-stressed group compared to the control group (p < 0.05). There were no differences in the blood cholesterol levels among groups. Ginseng administration in the immobilization-stressed group tended to reverse the lack of body weight gain and food intake, though not significantly. The ginseng-administered group showed a significant reversal in the stress-induced effect on spleen and thymus weight, increasing the tissue weights by 16% and 20%, respectively, compared to immobilization-stressed group (p<0.05). The plasma corticosterone level was significantly increased in the stressed group by 39 % compared to the control group (p<0.05), but ginseng administration significantly reversed the stress-induced increase in plasma corticosterone by 15 % compared to the immobilization-stressed group. The present study suggests that the anti-stress effect of ginseng is mediated by normalization of stress-induced changes in the circulating hormones and a reversal of tissue weight loss, thereby returning the body to normal homeostasis.

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피인용 문헌

  1. Validation of the LC-MS/MS Method for Ginsenoside Rb1 Analysis in Human Plasma vol.41, pp.12, 2012, https://doi.org/10.3746/jkfn.2012.41.12.1753
  2. Morphological Characterization, Chemical Components, and Biofunctional Activities ofPanax ginseng, Panax quinquefolium, andPanax notoginsengRoots: A Comparative Study vol.30, pp.2, 2014, https://doi.org/10.1080/87559129.2014.883631
  3. Microarray Analysis of Gene Expression by Ginseng Water Extracts in a Mouse Adrenal Cortex after Immobilization Stress vol.35, pp.1, 2011, https://doi.org/10.5142/jgr.2011.35.1.111
  4. Defense Genes Induced by Pathogens and Abiotic Stresses in Panax ginseng C.A. Meyer vol.35, pp.1, 2011, https://doi.org/10.5142/jgr.2011.35.1.001
  5. Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells vol.4, pp.4, 2010, https://doi.org/10.4162/nrp.2010.4.4.270