The Anti-tumor Effect of Soonkiwhajungtang with Doxorubicin in MKN-45 Conclusion

순기화중탕과 Doxorubicin의 병용이 MKN-45의 항암효과에 미치는 영향

  • 신민규 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 변준석 (대구한의대학교 한의과대학 비계내과학교실)
  • Published : 2004.06.01

Abstract

Objectives : To evaluate the anti-tumor and synergic effect of Soonkiwhajungtang with doxorubicin. Methods : The inhibitory concentration (IC), $IC_{50}$ and $IC_{90}$ of single use of doxorubicin and Soonkiwhajungtang with their concomitant treatment against MKN-45 (human stomach carcinoma) cell line were observed using MTT (microculture tetrazolium test) assay. In addition, their anti-tumor effects were also observed in xenograft nude mice models against the MKN-45 cell line. Results : Soonkiwhajungtang has only minimal direct anti-tumor effect against MKN-45 cell line but it reduced general depressed signs induced by implantation of the tumor cell lines and increased the total WBC and lymphocyte numbers. Conclusions : It is considered or expected that Soonkiwhajungtang extract reduces the critical toxicity of doxorubicin and has favorable synergic anti-tumor effect when administered concomitantly with doxorubicin.

References

  1. 대한의학협회지 v.36 no.3 암등록 사업과 암으로 인한 사망-연도별 추이 安敦姬
  2. 大韓韓方腫瘍學會誌 v.1 no.1 韓國韓醫學의 腫瘍硏究에 對한 現況 공현식;유봉하;박동원;유기원
  3. Cancer Res. v.61 no.8 Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart Sun X;Zhou Z;Kang YJ
  4. Crit Rev Oncol Hematol. v.37 no.2 Caelyx (stealth liposomal doxorubicin) in the treatment of advanced breast cancer Ranson MR;Cheeseman S;White S;Margison J
  5. 少陰人補中益氣湯과 瓦松이 抗癌 및 免疫反應에 미치는 影響 田炳旭
  6. 동의병리학회지 v.9 no.1 抗癌制 및 放射線 副作用에 대한 韓方療法 金東熙;金聖勳
  7. 大韓韓醫學會誌 v.16 no.2 포공영 분획의 간암세포에 대한 항암활성과 항암제와의 병용투여효과 金東熙;金聖勳
  8. 大韓韓方腫瘍學會誌 v.1 no.1 비기환이 항종양 면역반응에 미치는 영향 문병하;문구;문석재
  9. 陝西中醫 v.15 no.4 中醫藥對腫瘤補助治療的進展 王會玲
  10. 동의병리학회지 v.10 no.2 종양의 화학요법과 방사선요법의 부작용에 대한 한방약물요법 임락철(외)
  11. 癌症的中藥治療 1 楊寶仁
  12. 대한한방내과학회지 v.22 no.1 한약을 이용한 항암 실험 연구의 경향과 연구 방향 임성우
  13. 국역 萬病回春 공정현
  14. 東醫寶鑑 4 許浚
  15. 동의생리병리학회지 v.17 no.2 順氣和中湯이 indomethacin으로 유발된 위궤양에 미치는 영향 김상찬;이동언;권영규
  16. 圖說漢方診療要方 李哉熙
  17. Blood v.91 no.2 The tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Goralatide) protects from doxorubicin-induced toxicity: improvement in mice survival and protection of bone marrow stem cells and progenitors Masse A;Ramirez LH;Bindoula G;Grillon C;Wdzieczak-Bakala J;Raddassi K;Deschamps de Paillette E;Mencia-Huerta JM;Koscielny S;Potier P;Sainteny F;Carde P
  18. A guide to laboratory diagnosis (2nd ed.) Laboratory profiles of small animal diseases Sodikoff CH
  19. 豫防醫學과 保健學 2 金光湖;南喆鉉;李起男;李仙童;蘇敬順;康坼林등
  20. Hum Exp Toxicol. v.17 no.2 Preclinical toxicology of a novel polymeric antitumour agent: HPMA copolymer- doxorubicin (PK1) Duncan R;Coatsworth JK;Burtles S
  21. 암, 동서의학결합치료2 문구;정병학;김병주
  22. 半邊蓮과 항암제의 B16-F0 melanoma cell에 대한 항종양효과 장희일
  23. 抗癌生血湯이 Metaotrexate로 유발된 부작용과 면역기능 저하에 미치는 영향 이준용
  24. 中醫腫瘤學(上) 郁仁存
  25. 한글판 중의잡지 v.12 종양환자의 증형과 증형연구의 재고찰 金玲(외)
  26. 中醫免疫 劉正才;尤煥文
  27. 實用中醫內科學 方藥中(外)
  28. 黃帝內經讀解 裵秉哲(注解)
  29. 醫宗必讀 李仲梓
  30. 景岳全書 張介賓
  31. 衛生寶鑑 羅天益
  32. 임상본초학 辛民敎(편저)
  33. 大韓韓方腫瘍學會誌 v.1 no.1 일격 反胃와 위암과의 상관성에 대한 문헌적 고찰 황규동;류기원
  34. 大韓韓方腫瘍學會誌 v.2 no.1 위암의 동의학 및 동서의결합 치료에 관한 문헌적 고찰 윤성우;류봉하;박동원;류기원
  35. Cancer Genet Cytogenet v.64 no.2 Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene Rege-Cambrin G;Scaravaglio P;Carozzi F;Giordano S;Ponzetto C;Comoglio PM; Saglio G
  36. Gastric Cancer v.3 no.1 A model chemosensitivity test examining apoptosis in small specimens of gastric cancer Boku N;Ohtsu A;Yoshida S
  37. Anticancer Res. v.14 no.2A Antitumor activity of (2’’R)-4’-O-tetrahydropyranyl adriamycin on human gastric cancer cell lines in vitro and in vivo Saikawa Y;Kubota T;Kuo TH;Furukawa T;Kase S;Tanino H;Ishibiki K;Kitajima M; Hoffman RM
  38. Cancer Res. v.51 no.12 Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood Yokoyama M;Okano T;Sakurai Y;Ekimoto H;Shibazaki C;Kataoka K
  39. Jpn J Cancer Res. v.85 no.4 Improvement of therapeutic effect by using Fab’ fragment in the treatment of carcinoembryonic antigen-positive human solid tumors with adriamycin-entrapped immunoliposomes Uyama I;Kumai K;Yasuda T;Tagawa T;Ishibiki K;Kitajima M;Tadakuma T
  40. Phytomedicine v.7 no.2 Treatment of chemotherapy- induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa Sheng Y;Pero RW;Wagner H