Anti-Platelet Pentacyclic Triterpenoids from Leaves of Campsis grandiflora

  • Jin Jing Ling (Natural Products Research institute, Seoul National University) ;
  • Lee Yong Yook (Natural Products Research institute, Seoul National University) ;
  • Heo Jung Eun (Natural Products Research institute, Seoul National University) ;
  • Lee Sanghyun (Natural Products Research institute, Seoul National University) ;
  • Kim Jeong Mi (Natural Products Research institute, Seoul National University) ;
  • Yun-Choi Hye Sook (Natural Products Research institute, Seoul National University)
  • Published : 2004.04.01


Five pentacyclic triterpenoids, oleanolic acid (1), hederagenin (2), ursolic acid (3), tormentic acid (4) and myrianthic acid (5), were isolated from the methanol extract of the leaves of Campsis grandiflora, and structures of the compounds were established by the spectroscopic methods. Compounds 2, 3, 4, and 5 were isolated for the first time from the genus Campsis. All of the compounds ($IC_{50}$: 45.3, 32.8, 82.6, 42.9 and $46.2{\mu}M$ respectively) were as equivalently inhibitive as acetylsalicylic acid ($IC_{50}:57.0{\mu}M$) on epinephrine induced platelet aggregation.


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