Effects of ginkgo Biloba Extracts on Rthanol and Acetaldehyde-induced Oxidative Stress in Rat Brain

에탄올, 아세트알데히드-유도 뇌조직의 산화적 스트레스에 대한 은행잎 추출물의 항산화 효과

  • 박성욱 (대구가톨릭대학교 자연과학연구소) ;
  • 김종봉 (대구가톨릭대학교 자연과학연구소) ;
  • 허용 (대구가톨릭대학교 자연과학연구소) ;
  • 이선동 (상지대학교 한의과대학) ;
  • 김희정 ((주)경원엔터프라이즈) ;
  • 이인선 (계명대학교 전통미생물자원계발 및 산업화연구센터) ;
  • 한정호 (서울대학교 의학연구원) ;
  • 박영철 (대구가톨릭대학교 자연과학연구소)
  • Published : 2004.06.29

Abstract

Oxidative stress is one of the major reasons for brain aging and neurodegeneration. Ethanol and acetaldehyde increase the levle of oxidative stress in brain tissue resulting in aging and neurodegeneration related alcoholic dementia. Ginkgo biloba extracts are used as therapeutic and preventive agent for dementia. Here, it was investigated whether Ginkgo biloba extract show the effectiveness against ethanol- and acetaldehyde-induced oxidative stress in rat brain. Ethanol and acetaldehyde increased the level of oxidative stress by about 35% to 50% in rat brain tissue. However, Ginkgo biloba extracts reduced the level of ethanol- and acetaldehyde-induced oxidative stress. This result might reveal the link between the effectiveness of Ginkgo biloba extracts on oxidative stress and its effectiveness on alcoholic dementia.

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