Pharmacokinetics of Dehydroevodiamine Following Intravenous Administration in Rats

  • Kim, Seong-Yun (Department of Pharmacology, College of Medicine, The Catholic University of Korea) ;
  • Moon, Chan-Soo (Department of Pharmacology, College of Medicine, The Catholic University of Korea) ;
  • Choi, Yun-Sik (Department of Pharmacology, College of Medicine, The Catholic University of Korea) ;
  • Lee, Sang-Bok (Department of Pharmacology, College of Medicine, The Catholic University of Korea)
  • Published : 2004.02.21

Abstract

Dehydroevodiamine (DHED) is one of the bioactive components of the Chinese herbal medicine Wu-chu-yu-tang that has been shown to produce various pharmacological effects. In the present study, we investigated the pharmacokinetics of DHED after intravenous administration of two doses (2.5 and 5 mg/kg) in anesthetized rats. The plasma concentration of DHED was measured by reverse-phase high-performance liquid chromatography with UV detection. The mean area under the curve of the time-concentration profile was $21.9\;and\;53.9\;{\mu}g{\cdot}min/ml$ after the 2.5- and 5-mg/kg doses, respectively, and the volume of distribution was 1584.9 and 1580.6 ml following 2.5- and 5-mg/kg doses, respectively. Plasma concentration profiles versus time were compatible with a two-compartment model and first-order kinetics. The terminal elimination half-life was $91.8{\pm}16.6\;min$ and $78.7{\pm}11.9\;min$ in the dose of 2.5 and 5 mg/kg, respectively. This is the first report to study the pharmacokinetics of DHED in animals.

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