Decreased Expression of PTEN in Olfactory Bulb of Rat Pub after Naris Closure

  • Cho, Jae-Young (Department of Pharmacology, College of Medicine, Medical Science Research Institute, Kangwon National University) ;
  • Lee, Sang-Hyun (Department of Pharmacology, College of Medicine, Medical Science Research Institute, Kangwon National University) ;
  • Lee, Geon-Hee (Department of Pharmacology, College of Medicine, Medical Science Research Institute, Kangwon National University) ;
  • Chun, Wan-Joo (Department of Pharmacology, College of Medicine, Medical Science Research Institute, Kangwon National University) ;
  • Park, Yee-Tae (Department of Neuroscience, Medicine Science Research Institute, Kangwon National University) ;
  • Lim, So-Young (Department of Anesthesiology, College of Medicine, Hallym University) ;
  • Kim, Sung-Soo (Department of Pharmacology, College of Medicine and Department of Neuroscience, Medical Science Research Institute, Kangwon National University)
  • Published : 2004.02.21

Abstract

PTEN (phosphatase and tensin homolog) is a dual specific phosphatase antagonizing phosphoinositide 3-kinase activity, and has first been cloned as a tumor suppressor for glioma. Although the role of PTEN as a tumor suppressor has been well studied, little is known about signaling mechanisms regulating expression and/or activity of PTEN in the central nervous system. In this study, we investigated whether PTEN expression is regulated by sensory deprivation. P5 rat pups were unilaterally naris-closed, and olfactory bulbs were immunohistochemically analyzed with PTEN antibody at the $7^{th}$ day after naris closure. PTEN immunoreactivity was found to be down-regulated in both glomerular, external plexiform and subependymal cell layers, suggesting that odor deprivation signals down-regulate expression of PTEN in the olfactory bulb. To the best of our knowledge, this is the first report to suggest that PTEN expression is regulated by sensory deprivation signals in neonatal rats.

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