Fabrication and Evaluation of Active Drug Delivery System Using Polypyrrole

폴리피롤을 이용한 능동형 약물전달시스템의 제작 및 평가

  • Lee, Sang-Jo (School of Electrical, Electronics and Computer Engineering, Dankook University) ;
  • Lee, Seung-Ki (School of Electrical, Electronics and Computer Engineering, Dankook University) ;
  • Pak, James Jung-Ho (Department of Electrical Engineering, Korea Univ.)
  • 이상조 (단국대학교 전기전자컴퓨터공학부) ;
  • 이승기 (단국대학교 전기전자컴퓨터공학부) ;
  • 박정호 (고려대학교 전기공학과)
  • Published : 2004.01.30


This paper presents drug release properties of active drug delivery system (DDS) using volume change of polypyrrole (PPy). The incorporation of various chemical substances into the PPy and controlling its release with the externally applied voltage to the PPy are possible. In order to confirm possibility for drug delivery system qualitatively, indicator(phenol red) was examined as a dopant of PPy. The applied voltage to the PPy electrode was set to -2 V and this negative voltage makes the anionic indicator released in saline solution. After qualitative analysis, in order to confirm quantitative drug release characteristic of PPy, salicylate which is one of the aspirin substance was used as a dopant of PPy. As a result, the salicylate release characteristics with time was thoroughly investigated while varying the electrode area, polymerization time, the applied voltage for drug release. Based on these quantitative results, a preliminary experiment was carried out to check the feasibility of the PPy applicable to the neuronal system.



  1. J. W. Gardner and P. N. Battlett, 'Application of coudusting polymer technology in microsystem,' Sensors and Actuators A, vol. 51. pp. 57-66, 1995
  2. E. Smela, O, Inganas, and I. Lundstorm, 'Conjucting polymer as artificial muscle : challenges and possibilities,' J. Micromech Microeng., vol. 3, pp. 203-205, 1993
  3. Q. Xie, S. Kuwabata, and H. Yoneyama, 'EQCM studies on polypyrrole in aqueous solution,' J. Electroanalytical Chem., vol. 420, pp. 219-225, 1997
  4. E. Smela, O, Inganas, and I. Lundstorm, 'Microrobots controlled byconducting polymer muscles : multi-hinged, folding actuator,' Proc. of Int. Symp. on MIMR, pp. 79-82, 1995
  5. K. Kontturi, P.Pentti, and G.Sundholm, 'Polypyrrole as a model membrane for drug delivery,' J. Electroanalytical Chem., vol. 453, pp. 231-238, 1998
  6. Jurgen Heinze, 'Electronically conducting Polymers,' Topics in Current Chemistry, vol. 152, pp. 1-47, 1990
  7. 안호정, 차승은, 이상조, 박정호, 이승기, '공기 중에서 동작하는 전도성 고분자 액추에이터의 제작,' 2001년도 대한전기학회 하계학술대회 논문집, C권, pp. 1878-1880, 2001