Hepatoprotective Effect of the Methanol Fraction of Chinese Cabbage on Liver Injury in Rats Treated by bromobenzene

Chinese Cabbage 잎과 뿌리가 메탄올층의 Bromobenzene 간손상에 대한 보호효과

  • Lee Hyo Jung (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim Kwan Hyun (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee Eun Ok (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Choi Jong Won (College of Pharmacy, Kyongsung University) ;
  • Kang Kyung Sun (Department of Veterinary Public Health, College of Veterianry Medicine, Seoul university) ;
  • Yoon Byong Su (Department of Biology, Kyonggi University) ;
  • Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
  • 이효정 (경희대학교 동서의학 대학원) ;
  • 김관현 (경희대학교 동서의학 대학원) ;
  • 이은옥 (경희대학교 동서의학 대학원) ;
  • 최종원 (경성대학교 약학과) ;
  • 강경선 (서울대학교 수의과대학) ;
  • 윤병수 (경기대학교 생물학과) ;
  • 김성훈 (경희대학교 동서의학 대학원)
  • Published : 2003.10.01

Abstract

Chinese cabbage is a vegetable of Cruciferous family. It was usually consumed as Kimchi. It was known to have amount of vitamin c. Recently the trend for the development of functional food combined with oriental herbs. For this aim the study was performed to evaluate the hepatoprotective effect via antioxidant activity of leaf and root of Sanchon Chinese cabbage(Brassica campetris L.) comparatively. The methanol extracts of Chinese cabbage were tested for investigating the effects on the formation of lipid peroxide and the activities of free radical generating enzyme in vitro in bromobenzene-treated rats. The methanol extracts of chinese cabbage reduced bromobenzene-induced hepatic lipid peroxidation and inhibited the activity of xanthine oxidase. The methanol extracts of chinese cabbage did not activate amionopyrine N-demethylase, aniline hydroxylase and glutathione S-transferase. Epoxide hydrolase activity was decreased by bromobenzene, which was restored by pretreatment of the methanol extracts of chinese cabbage. The results suggest that the methanol extracts of Chinese cabbage is reduced by enhancing the activity of epoxide hydrolase.

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