Preventive Nutrition and Food Science
- Volume 8 Issue 4
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- Pages.390-394
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- 2003
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- 2287-1098(pISSN)
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- 2287-8602(eISSN)
DOI QR Code
Gene Expression Profile of Zinc-Deficient, Homocysteine-Treated Endothelial Cells
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Kwun, In-Sook
(Department of Food Science and Nutrition, Andong National University) ;
- Beattie, John H. (Cellular Integrity Division, Rowett Research Institute, Aberdeen, Scotland, United Kingdom)
- Published : 2003.12.01
Abstract
In the post-genome period, the technique for identifying gene expression has been progressed to high throughput screening. In the field of molecular nutrition, the use of screening techniques to clarify molecular function of specific nutrients would be very advantageous. In this study, we have evaluated Zn-regulated gene expression in Zn-deficient, homocystein-treated EA.hy926 cells, using cDNA microarray, which can be used to screen the expression of many genes simultaneously. The information obtained can be used for preliminary assessment of molecular and signaling events modulated by Zn under pro-atherogenic conditions. EA.hy926 cells derived from human umbilical vein endothelial cells were cultured in Zn-adequate (control, 15
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