Pine Needle Oil and Korean Medicinal Herb Complex Protect Hyperlipidemia and Liver Cell Damage Induced by Alcohol

  • Park, Kap-Joo (Department of Biological Sciences, Konkuk University) ;
  • Kim, Kang-Sung (Department of Food Science and Nutrition, Yongin University) ;
  • Ahn, Ki-Heung (Department of Biological Sciences, Konkuk University) ;
  • Rhee, Joon-Shick (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)
  • Published : 2003.12.01

Abstract

The effect of treatment with pine needle oil complex (complex of pine needle oil and Korean medicinal herbs) upon rat hepatocytes exposed to alcohol was investigated. We compared body weight gain and ratios of liver and kidney to body weight and the serum biochemistry of rats administered both alcohol and Pine needle oil complex to control rats treated with alcohol alone. Pine needle oil complex treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. These data suggest that Pine needle oil complex represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.

References

  1. J. Clin. Inverst v.49 Effects of chronic ethanol feeding on serum lipoprotein metabolism in the rat Baraona E;CS Lieber
  2. in Alcohol and Aldehyde Metabolizing System Bode JC;Thurman RG(ed.);T Yontani(ed.);JR Williamson(ed.);B Change(ed.)
  3. Encyclopedia of Herbs and Their Uses Bown D.
  4. The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 12th ed. Budavari S.(ed.)
  5. International Collation of Traditional and Folk Medicine. But PPH (et al. eds.)
  6. Atheroscl. Rev. v.21 Serum Lipids and risk of coronary artery disease Castelli WP;PW Wilson;D Levy;K Anderson
  7. Am. J. Clin. Nutr. v.38 Selenium and acute alcoholism Cutta SK;Miller Pa;:B Greenberg;OA Levander
  8. Am. J. Clin. Nutr. v.33 Effects of alcohol ingestion on lipids and lipoproteins in normal men:isocaloric metabolic studies Glueck CJ;E Hogg;C Allen;PS Gartside
  9. A Modern Herbal Grieve M.
  10. Am. J. Clin. Nutr. v.42 Alcoholconsumption, nutrient intake and relative body weight among U.S. adults Gruchow HW;KA Sobocinski;JJ Barboriak;JG Scheller
  11. Br. J. Nutr. v.54 Influence of chronic ethanol intake on obesity, liver steatosis and hyperlipidaemia in the zucker fa/fa rat Karsentry BC;F Chanussot;M Ulmer;G Debry
  12. Free Radic. Biol. Med. v.30 Ebselen prevents early alcohol-induced liver injury in rats Kono H;GE Arteel;I Rusyn;H Sies;RG Thurman
  13. Am. J. Physiol. Gastrointest. Liver Physiol v.280 Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat Kono H;I Rusyn;T Uesugi;S Yamashina;HD Connor;A Dikalova;RP Mason;RG Thurman
  14. J. Am. Diet. Assoc. v.58 Dietary management of hyperlipoproteinmia Levy RI;M Bonnell;ND Ernst
  15. Pathol. Biol. v.49 Alcoholic liver injury:pathogenesis and therapy in 2001 Lieber CS
  16. Chin. Med. J.(Engl). v.102 Pharmacological actions and clinical use of Fructus schizandrae Liu GT
  17. Indian Materia Medica Nadkarni KM
  18. Alcohol. Clin. Exp. Res. v.25 Influence of alcohol intake on risk for increased low-density lipoprotein cholesterol in middleaged Japanese man Nakanishi N;H Yoshida;K Nakamura;H Kawashimo;K Tatara
  19. Phamacology v.7 The energy cost of the metabolism of drugs, including ethanol Piola RC;CS Lieber
  20. J. Nutr. v.105 Energy wastage in rats given drugs that induce microsomal enzymes Piola RC;CS Lieber
  21. J. Am Med. Assoc. v.253 Cholesterol and coronary heart disease Rahimtoola SH
  22. Disease of the liver and Biliary System v.8 Sherlock S
  23. Taber's Cyclopedic Medical Dictionary, 9th ed Taber CW
  24. J. Nutr. v.100 Impaired lipid and vitamin E absorption related to atrophy of the pancreas in selenium-deficient chicks Thompson JN;ML Scott
  25. Hepatology v.12 Insights into the pathogenesis of alcoholic liver necrosis and fibrosis Tsukamoto H;K Gaal;SW French
  26. Hepatology v.6 Ethanol-induced liver fibrosis in rats fed high fat diet Tsukamoto H;SJ Towner;LM Ciofalo;SW French