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Effect of Kimchi and Its Ingredients on the Growth of Helicobacter pylori

  • Jung, Keun-Ok (Dept. of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University) ;
  • Kil, Jeung-Ha (Dept. of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University) ;
  • Kim, Kwang-Hyuk (Dept. of Food Science and Nutrition, and Kimchi Research Institute, Pusan National University) ;
  • Park, Kun-Young (Dept. of Microbiology, Kosin Medical College)
  • Published : 2003.06.01

Abstract

Effects of kimchi and its ingredients, vitamin C and $\beta$-sitosterol on the growth of Helicobacter pylori were investigated. Three kimchi variations were studied: a standard recipe (kimchi I) and two functional variations for cancer prevention and treatment made with organically grown ingredients (kimch II and III). Methanol extracts and juices from kimchi I and III did not inhibit the growth of H. pylori. However, 10 mm and 12 mm inhibition zones were formed by methanol extract and juice from kimchi II, which had higher concentrations of red pepper powder (RPP) than those of kimchi I and III. Among the major kimchi ingredients, methanol extracts of RPP, garlic and ginger substantially inhibited the growth of H. pylori. The maximal inhibition zone (30 mm) was attained with garlic treatment. Inhibitory effects of the RPP, garlic and the sub-ingredient mixture (prepared with radish, garlic, RPP, ginger, green onion, sugar and fermented anchovy juice) on H. pylori were decreased by lactic acid bacteria fermentation. Neither the fermented garlic nor the fermented sub-ingredient mixture inhibited the growth of H. pylori. But, the inhibition Bone of fermented RPP was 12 mm, which was less than the 16 mm inhibition zone formed by the non-fermented RPP. Vitamin C and $\beta$-sitosterol which are known to be functional active compounds of kimchi also showed no inhibitory effect on the growth of H. pylori after 3 days of incubation. Further study is needed to determine why the inhibitory effect is removed or decreased by lactic acid fermentation, and to determine if fresh kimchi and lactic acid bacteria of kimchi can inhibit the growth of H. pylori.

References

  1. Park KY. 1995. The nutritional evaluation, and antimutagenic and anticancer effects of kimchi. J Korean Soc Food Nutr 24: 169-182
  2. Cheigh HS, Park KY. 1994. Biochemical, microbiological and nutritional aspects of kimchi (Korean fermented vegetables products). Crit Rev Food Sci Nutr 34: 175-203 https://doi.org/10.1080/10408399409527656
  3. Hwang SY, Hur YM, Choi YH, Rhee SH, Park KY, Lee WH. 1997. Inhibitory effect of kimchi extract on mutagenesis of aflatoxin B₁. Environ Muta Carcino 17: 133-137
  4. Kim KH, Kim SH, Rhee SH, Park, KY 1998. Effects of kimchi extracts on interleukin-2 production and natural killer cell activity in mice. J Food Sci Nutr 3: 282-286
  5. Kim ND, Hur YM, Rhee SH, Park KY. 1996. Effects of kimchi extract on the development of multicellular structures from rat mammary organoids cultured in matrigel. J Food Sci Nutr 1: 168-173
  6. Choi MW, Kim KH, Kim SH, Park KY. 1997. Inhibitory effects of kimchi extracts on carcinogen-induced cytotoxicity and transformation in C3H/10T1/2 cell. J Food Sci Nutr 2: 241-245
  7. Choi MW, Kim KH, Park KY. 1997. Effects of kimchi extracts on the growh of sarcoma- 180 cells and phagocytic activity of mice. J Korean Soc Food Sci Nutr 26: 254-260
  8. Ali AT, Chowdhury MN, al Humayyd MS. 1991. Inhibitory effect of natural honey on Helicobacter pylori. Trop Gastroenterol 12: 139-143
  9. Jones NL, Shabib S, Sherman PM. 1997. Capsaicin as an inhibitor of the growth of the gastric pathogen Helicobacter pylori. FEMS Microbiol Lett 146: 223-227 https://doi.org/10.1111/j.1574-6968.1997.tb10197.x
  10. Malaty HM, Kim JG, El-Zimaity HM, Graham DY. 1997. High prevalence of duodenal ulcer and gastric cancer in dyspeptic patients in Korea. Scand J Gastroenterol 32: 751-754 https://doi.org/10.3109/00365529708996529
  11. Eaton KA, Brooks CL, Morgan DR, Krakowka S. 1991. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun 59: 2470-2475
  12. O'Gara EA, Hill DJ, Maslin DJ. 2000. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. Appl Environ Microbiol 66: 2269-2273 https://doi.org/10.1128/AEM.66.5.2269-2273.2000
  13. Cellini L, Di Campli E, Masulli M, Di Bartolomeo S, Allocati N. 1996. Inhibition of Helicobacter pylori by garlic extract (Allium sativum). FEMS Immunol Med Microbiol 13:273-277 https://doi.org/10.1111/j.1574-695X.1996.tb00251.x
  14. Kockar C, Ozturk.M, Bavbek N. 2001. Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin. Acta Medica (Hradec Kralove) 44: 97-100
  15. Malaty HM, Kim JG, Kim SD, Graham DY. 1996. Prevalence of Helicobacter pylori infection in Korean children: inverse relation to socioeconomic status despite a uniformly high prevalence in adults. Am J Epidemiol 143: 257-262 https://doi.org/10.1093/oxfordjournals.aje.a008736
  16. Malekzadeh F, Ehsanifar H, Shahamat M, Levin M, Colwell RR. 2001 Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori. Int J Antimicrob Agents 18: 85-88 https://doi.org/10.1016/S0924-8579(01)00352-1
  17. Choi WY, Park KY. 1998. Brining property and antimutagenic effects of organic Chinese cabbage kimchi. J Food Sci Nutr 3: 287-291
  18. Choi WY, Park KY. 1999. Anticancer effects of organic Chinese cabbage kimchi. J Food Sci Nutr 4: 113-116
  19. Kim JY, Rhee SH and Park KY. 2000. Enhancement of anticancer activities of kimchi by manipulating ingredients.J Food Sci Nutr 5: 126-130
  20. Cho EJ, Lee SM, Rhee SH, Park KY. 1998. Studies on the standardization of Chinese cabbage kimchi. Korean J Food Sci Technol 30: 324-332
  21. Sobala GM, Schorah CJ, Sanderson M, Dixon MF, Tompkins DS, Godwin P, Axon AT. 1989. Ascorbic acid in the human stomach. Gastroenterology 97: 357-363 https://doi.org/10.1016/0016-5085(89)90071-1
  22. Chuang CH, Sheu BS, Huang AH, Yang HB, Wu JJ. 2002. Vitamin C and E supplements to lansoprazole-amoxicillin-metronidazole triple therapy may reduce the eradication rate of metronidazole-susceptible Helicobacter pylori infection. Helicobacter 7: 310-316 https://doi.org/10.1046/j.1523-5378.2002.00095.x
  23. Cho EJ. 1999. Standardization and cancer chemopreventive activities of Chinese cabbage kimchi. PhD. Thesis, Pusan National University, Korea
  24. Midolo PD, Lambert JR, Hull R, Luo F, Grayson ML. 1995.In vitro inhibition of Helicobacter pylori NCTC 11637 by organic acids and lactic acid bacteria. J Appl Bacteriol 79: 475-479 https://doi.org/10.1111/j.1365-2672.1995.tb03164.x
  25. Kabir AM, Aiba Y, Takagi A, Kamiya S, Miwa T, Koga Y. 1997. Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model. Gut 41: 49-55 https://doi.org/10.1136/gut.41.1.49
  26. Coconnier MH, Lievin V, Hemery E, Servin AL. 1998. Antagonistic activity against Helicobacter infection in vitro and in vivo by the human Lactobacillus acidophilus strain LB.Appl Environ Microbiol 64: 4573-4580
  27. Choi SM, Jeon YS, Park KY. 2000. Comparison of quality of red pepper powders produced in Korea. Korean J Food Sci Technol 32: 1251-1257
  28. Choi WY. 1998. Characteristics of organic Chinese cabbage and antimutagenic and anticancer effects of organic Chinese cabbage kimchi. MS Thesis, Pusan National University, Korea
  29. Sobala GM, Schorah CJ, Shires S, Lynch DA, Gallacher B, Dixon MF, Axon AT. 1993. Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations. Gut 34: 1038-1041 https://doi.org/10.1136/gut.34.8.1038

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