Modeling and Synthesis of Novel Hydroxyethyl 2-iminothiazolines

새로운 hydroxyethyl 2-iminothiazoline 유도체의 모델링 및 합성

  • Hahn, Hoh-Gyu (Organic Chemistry Lab, Korea Institute of Science and Technology) ;
  • Nam, Kee-Dal (Organic Chemistry Lab, Korea Institute of Science and Technology) ;
  • Jeon, Jin-Ho (Department of Chemistry, Kyonggi University) ;
  • Mah, He-Duck (Department of Chemistry, Kyonggi University)
  • 한호규 (한국과학기술연구원 생체과학연구부) ;
  • 남기달 (한국과학기술연구원 생체과학연구부) ;
  • 전진호 (경기대학교 화학과) ;
  • 마혜덕 (경기대학교 화학과)
  • Published : 2003.06.30

Abstract

Modeling and synthesis of novel hydroxyethyl 2-iminothiazolines were carried out through molecular modification of lead compound, 2-phenyliminothiazolines 1, for the purpose of development of new fungicidal agrochemicals. Oxygen atom of the hydroxyethyl group in 2-iminothiazolines 3 would locate in the proximity of the imino carbon at C-2 of 2-iminothiazoline moiety through neighboring group participation, and so that it would affect the biological activity of the molecule. Reaction of $\gamma$-chloroacetoacetanilides 5 with hydroxyethylureas 6 gave 29 kinds of new corresponding hydroxyethyl 2-iminothiazolines 3 in high yields.

Keywords

new fungicidal agrochemicals;pyricularia oryzae;neighboring group participation;modeling

References

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