Essentiality of Histidine in Ruminant and Other Animals Including Human Beings

  • Onodera, Ryoji (Laboratory of Animal Nutrition and Biochemistry, Miyazaki University)
  • Published : 2003.03.01


Concept and establishment of essential amino acids in animals and human beings rendered immeasurable contributions to animal production and human health. In ruminant animals, however, essential amino acids have never been completely established. The present review proposes a hypothesis that histidine may not be an essential amino acid for normal growing cattle (Japanese black) at least at the growing stage after about 450 kg of body weight on the basis of the experimental results of histidinol dehydrogenase activities in some tissues of the cattle together with hints from which the hypothesis was derived. At the same time, histidinol dehydrogenase activities in liver, kidney and muscle of swine, mouse, fowl and wild duck will be shown and the essentiality of histidine in these animals will be discussed. Finally, the essentiality of histidine for adult human will briefly be discussed.


  1. Albanese, A. A., L. E. Holt Jr., J. E. Frankston and V. Irby. 1944. Observations on a histidine deficient diet in man. Bull. Johns Hopkins Hosp. 74:251-258.
  2. Allison, M. J. 1969. Biosynthesis of amino acids by ruminal microorganisms. J. Anim. Sci. 29:797-807.
  3. Andorn, N. and J. Aronovitch. 1982. Purification and properties of histidinol dehydrogenase from Escherichia coli. B. J. Gen. Microbiol. 128: 579-584.
  4. Bergen, W. G., D. B. Purser, J. H. Cline. 1968. Determination of limiting amino acids of rumen-isolated microbial proteins fed to rat. J. Dairy Sci. 51: 1698-1700.
  5. FAO. 1970. Amino Acid Content of Foods and Biological Data on Proteins in FAO Nutritional Studies, No. 24. (ed by Food Policy and Food Science Service, Nutrition Division, FAO, Rome, 1970).
  6. Kotb, A. R. and R. L. Wixom. 1971. Inability of the growing rat to substitute L-histidinol for L-histidine. J. Nutr. 101:1493-1498.
  7. Levy, L., and M. J. Coon. 1952. Histidine synthesis in yeast and human liver. Fed. Proc. 11:248(Abstract)
  8. McLaughlan, J. M. 1964. Blood amino acid studies. 5. Determination of the limiting amino acid in diets. Canadian J. Biochem. 42:1353-1360.
  9. Okitani, A. 1999. 'Niku no Kagaku (Meat Science)' ed. by A. Okitani. Asakura. Tokyo.
  10. Rose, W. C., W. J. Haines, D. T. Warner and J. E. Johnson. 1951a. The amino acid requirements of man. II. The role of threonine and histidine. J. Biol. Chem. 188:49-58.
  11. Rose, W. C., W. J. Haines and D. T. Warner. 1951b. The amino acid requirements of man. III. The role of isoleucine: additional evidence concerning histidine. J. Biol. Chem. 193:605-612.
  12. Sauer, F. D., J. D. Erfle and S. Mahadevan. 1975. Amino acid biosynthesis in mixed rumen cultures. Biochem. J. 150:357-372.
  13. Wadud, S., R. Onodera, and M. M. Or-Rashid. 2001b. Synthesis of histidine in liver and kidney of cattle and swine. Anim. Sci. 72:253-256.
  14. Japanese Feeding Standard for Poultry. 1997. Agriculture, Forestry and Fisheries Research Council Secretariat (ed). MAFF. Central Association of Livestock Industry. Tokyo.
  15. Rose, W. C. 1937. The nutritive significance of the amino acids and certain related compounds. Science 86:298-300.
  16. Japanese Feeding Standard for Beef Cattle. 2000. Agriculture, Forestry and Fisheries Research Council Secretariat (ed). MAFF. Central Association of Livestock Industry. Tokyo.
  17. Storm, E. and E. R. Orskov. 1984. The nutritive value of rumen Micro organisms in ruminants. 4. The limiting amino acids of microbial protein in growing sheep determined by a new approach. Br. J. Nutr., 52:613-620.
  18. Japanese Feeding Standard for Swine. 1998. Agriculture, Forestry and Fisheries Research Council Secretariat (ed). MAFF. Central Association of Livestock Industry. Tokyo.
  19. Metges, C. C., K. J. Petzke and V. R. Young. 1999. Dietary requirements for indispensable amino acids in adult humans: New concepts, methods of estimation, uncertainties and challenges. Mannu. Nutr. Metab. 43:267-276.
  20. Morimoto, H. 1974. Shiryogaku (Feeds and Feeding). Yokendo. Tokyo.
  21. Czerkawski, J. W. 1976. Chemical composition of microbial matters in the rumen. J. Sci. Food Agric. 27:621-632.
  22. Richardson, C. R. and E. E. Hatfield. 1978. The limiting amino acids in growing cattle. J. Anim. Sci. 46:740-745.
  23. Meyer, C. E., W. C. Rose. 1936. The spatial configuration of $\alpha$-amino-$\beta$-hydroxy-n-butyric acid. J. Biol. Chem. 115:721-729.
  24. Virtanen, A. I. 1966. Milk production of cows on protein-free feed. Science 153:1603-1614.
  25. Wadud, S., M. M. Or-Rashid and R. Onodera. 2002. Method for determination of histidine in tissues by isocratic highperformance liquid chromatography and its application to the measurement of histidinol dehydrogenase activity in six cattle organs. Journal of Chromatography B, 767:369-374.
  26. McCoy, R. H., C. E. Meyer, W. C. Rose. 1935. Feeding experiments with mixture of highly purified amino acids. VIII. Isolation and identification of a new essential amino acid. J. Biol. Chem. 112:283-302.
  27. Voeltz, W. 1920. Der Ersatz des Nahrungseiweisses durch Harnstoff beim wachsenden Wiederkaeuer. Der Futter des nach dem Beckmannschen Verfahren aufgeschlossenen Strohs und der Spreu. Biochem. Z. 102:151-227.
  28. Kopple, J. D. and M. E. Swendseid. 1975. Evidence that histidine is an essential amino acid in normal and chronically uremic man. J. Clin. Invest. 55:881-891.
  29. Wixom, R. L. and H. L. Anderson. 1979. Histidine – Limited synthesis in normal, adult man. Histidine: Metab., Clin. Aspects, Ther. Use., Internatl. Workshop, 1st, pp. 19-33.
  30. Fuller, M. F. and P. J. Garlick. 1994. Human amino acid requirements: Can the controversy be resolved? Ann. Rev. Nutr. 14: 217-241.
  31. Ishibashi, T. 2002. 'Dobutsu Eiyo Shikenho (Methods for Animal Nutrition Experiments)' ed. by T. Ishibashi. Yokendo Ltd. Tokyo.
  32. Wadud, S., R. Onodera and M. M. Or-Rashid. 2001a. Studies on the possibility of histidine biosynthesis from histidinol, imidazolepyruvic acid, imidazoleacetic acid, and imidazolelactic acid by mixed ruminal bacteria, protozoa and their mixture in vitro. Appl. Microbiol. Biotechnol. 55:219-225.
  33. Fuerst, P. 1972. $^{15}N$-Studies in severe renal failure. II. Evidence for the essentiality of histidine. Scand. J. Clin. Lab. Invest. 30:307-312.
  34. Land, H. and A. I. Virtanen. 1959. Ammonium salts as nitrogen source in the synthesis of protein by the ruminant. Acta Chem. Scand. 13:489-496.
  35. Nagai, A. and A. Scheidegger. 1991. Purification and characterization of histidinol dehydrogenase from cabbage. Arch. Biochem. and Biophys. 284: 127-132.
  36. Onodera, R., S. Wadud and M. M. Or-Rashid. 2001. Is histidine an essential amino acid in ruminant animals? Asian-Aust. J. Anim. Sci. 14 (Special Issue):123-130.
  37. Nimrick, K., E. E. Hatfield, J. Kaminski and F. N. Owens. 1970. Qualitative assessment of supplemental amino acid needs for growing lambs fed urea as the sole nitrogen source. J. Nutr. 100:1293-1300.
  38. Snyderman, S. E., A. Boyer, E. Roitman, L. E. Holt, JR. and P. H. Prose. 1963. The histidine requirement of the infant. Pediatrics 31:786-801.
  39. Rose, W. C., W. J. Haines, J. E. Johnson and D. T. Warner. 1943. Further experiments on the role of the amino acids in human nutrition. J. Biol. Chem. 148:457-458.
  40. Onodera, R. and K. Koga. 1987. Effect of inhabitation by rumen protozoa on the nutritive value of protein in rumen contents. Agric. Biol. Chem. 51:1417-1424.
  41. Buttery, P. J. and A. N. Foulds. 1985. Amino acid requirements of ruminants. In: Recent Advances in Animal Nutrition-1985. (Haresign, W. and D. J. A. Cole eds. Butterworths. London.) pp. 257-271.

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