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The Effect of Willow Leaf Extracts on Human Leukemic Cells in Vitro

  • El-Shemy, Hany A. (Department of Biochemistry, Faculty of Agriculture, Cairo University) ;
  • Aboul-Enein, Ahmed M. (Department of Biochemistry, Faculty of Agriculture, Cairo University) ;
  • Aboul-Enein, Mostafa I. (Department of Clinical Pathology, National Cancer Institute, Cairo University) ;
  • Issa, Sohair I. (Department of Clinical Pathology, National Cancer Institute, Cairo University) ;
  • Fujita, Kounosuke (Faculty of Applied Biological Science, Hiroshima University)
  • Received : 2003.01.05
  • Accepted : 2003.02.25
  • Published : 2003.07.31

Abstract

The young developing leaves of willow (Salix safsaf, Salicaceae) trees have antileukemic activity. After a 24-h incubation in vitro, the crude water extracts of the leaves killed a majority of the blasts of acute myeloid leukemia (AML, 73.8%).

Keywords

Acute myeloid leukemia;Human leukemic cell;Willow leaf

References

  1. Adamkiewicz, V. W. and Fortier, A. A. (1961) Passage of salicin and saligenin across the wall of the rat ilcum. Can. J. Biochem. Physiol. 39, 1097-1099. https://doi.org/10.1139/o61-111
  2. Bennett, J. M., Catovsky, D., Daniel, M. T., Flandrin, G., Galton,D. A. G., Gralnick, H. R. and Sultan C. (1976) Proposals for the classification of the acute myeloid leukemia. Br. J. Haematol. 33, 451-458. https://doi.org/10.1111/j.1365-2141.1976.tb03563.x
  3. Bravo, L. (1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr. Rev. 56, 317-333.
  4. Han S. -S., Keum Y. -S., Seo, H. -J. and Surh, Y. -J. (2002) Curcumin suppresses activation of NF-${\kappa}B$ and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J. Biochem. Mol. Biol. 35, 337-342. https://doi.org/10.5483/BMBRep.2002.35.3.337
  5. Kupchan, M. S., Uchida, I., Branfman, A. R., Caily, R. G. and Yufei, B. (1976) Antileukemic principles isolated from Euphorbiaceae plants. Science 191, 571-572. https://doi.org/10.1126/science.1251193
  6. Leven, M., Berghe, V. D., Martins, F., Vlietinck, A. J. and Lammas, E. (1979) Screening of higher plants for biological activities, 1. Antimicrobial activity. J. Med. Plant Res. 36, 311-321. https://doi.org/10.1055/s-0028-1097277
  7. Matsumoto, Y., Ohsako, M., Takadate, A. and Goto, S. (1993) Reduction of erythrocyte membrane permeability and protein binding of low molecular weight drugs following glycoside gerivatization. J. Pharm. Sci. 82, 399-403. https://doi.org/10.1002/jps.2600820413
  8. Metzner, J., Hirschelmann, R., Hiller, K., Fotsch, G., Pfeifer, S.,Bartoszek, M., Franke, P. and Hiller, K. (1989) Biotransformation of phenolglycosides leiocarposide and salicin. Pharmazie 44, 555-558.
  9. Steinegger, E. and Hel, H. (1972) Analytische und biologische Untersuchungen an Salicaceen Wirkstoffen, insbesondere an Salicin. II. Biologische Untersuchungen. Pharm. Acta Helv. 47, 222-234.

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