Estimation of Joint Risks for Developing Uterine Cervix Cancer in Korea

한국인 자궁경부암의 복합위험도 추정

  • Yoon, Ha-Chung (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Shin, Ae-Sun (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Park, Sue-Kyung (Department. of Preventive Medicine. KonKuk University College of Medicine) ;
  • Jang, Myung-Jin (Department of Statistics, Seoul National University) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine)
  • 윤하정 (서울대학교 의과대학 예방의학교실) ;
  • 신애선 (서울대학교 의과대학 예방의학교실) ;
  • 박수경 (건국대학교 의과대학 예방의학교실) ;
  • 장명진 (서울대학교 자연과학대학 통계학과) ;
  • 유근영 (서울대학교 의과대학 예방의학교실)
  • Published : 2002.09.01

Abstract

Objective : This study was aiming at estimating the joint effects of various risk factors associated with uterine cervix cancer in Korea. Methods : Data obtained from a case-control study were analyzed with a multiplicative model. Results : After adjustment for age and husband's educational attainments, the family history of cervical cancer (OR=2.1, 95% CI=1.2-3.9), unstable marital status due to separation, by death or divorce, etc. (OR=2.8, 95% CI=1.7-4.6), and a large number of deliveries ($\geq$3 vs. nulliparous OR=6.5, 55% CI=1.4-29.0) increased the risk of uterine cervix cancer, Conversely, first sexual intercourse at an older age ($\geq$25 years vs. <19 years OR=0.4, 95% CI=0.2-0.6) and husband's circumcision (OR=0.7, 95% CI=0.5-1.0) decreased the risk. In the multiplicative model, the highest joint risk (OR=39.2, 95% CI 5.9-258.9) was observed in women with a family history of uterine cervical cancer, an unstable marital status, where the ex-husband was not circumcised, with 3 or more delivery experiences, and having her first sexual intercourse when younger than 19 years of age. However, women without a family history of uterine cervix cancer, married to a circumcised husband, having had her first sexual intercourse at 25 years or older, and nulliparous, showed the lowest joint effect (OR=0.3, 95% CI=0.1-0.5). Conclusion : As carcinogenesis is a complex action involving various factors, we consider a joint effects approach to be appropriate in an epidemiological study on risk factors for uterine cervix neoplasms cervix neoplasm.

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