Synthesis and Cytotoxic Activity-II, Aminoacetyl Derivatives

루판 유도체의 합성 및 세포독성-II: 아미노아세칠 유도체

  • You, Young-Jae (College of Pharmacy, Chungnam National University) ;
  • Kim, Yong (College of Pharmacy, Chungnam National University) ;
  • Nam, Nguyen-Hai (College of Pharmacy, Chungnam National University) ;
  • Ahm, Byung-Zun (College of Pharmacy, Chungnam National University)
  • Published : 2002.10.01


To increase the water solubility, sixteen lupane derivatives bearing aminoacetyl moiety at C3 were synthesized. Their cytotoxic activities against three cancer cell lines, SK-MEL-2, A549, and B16, were tested. Among them, six derivatives showed significant cytotoxic activity.


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