Lupane Derivatives-I: Synthesis and Cytotoxic Activity

루판 유도체의 합성 및 세포독성-I

  • You, Young-Jae (College of Pharmacy, Chungnam National University) ;
  • Kim, Yong (College of Pharmacy, Chungnam National University) ;
  • Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
  • 유영제 (충남대학교 약학대학) ;
  • 김용 (충남대학교 약학대학) ;
  • 안병준 (충남대학교 약학대학)
  • Published : 2002.10.01


To observe the structure-activity relationship of lupane derivatives both on cytotoxic and antiangiogenic activity, twelve lupane derivatives were prepared; their antiangiogenic and cytotoxic activities were evaluated. Among them, four compounds were more cytotoxic than betulinic acid. Carboxylic acid at C28 seemed to be essential for cytotoxic activity. But, a selective cytotoxicity toward SK-MEL-2 was not observed. As for antiangiogenic activity, none of the compounds except lupeol showed antiangiogenic activity at 30 $\mu\textrm{g}$/mL.


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