Isolation and in vivo Activities of Antifungal Compounds from Myxococcus sp. JW154 (Myxobacteria).

점액세균 Myxococcus sp. JW154로 부터 항균물질의 분리 및 식물병원균에 대한 in vivo 활성

  • 안종웅 (한국화학연구원 화학물질부) ;
  • 김병섭 (강릉대학교 식물응용과학과)
  • Published : 2002.06.01

Abstract

Two bithiazole-type antibiotics were isolated from the culture broth of a Myxococcus species which isolated from the marine sediment off the coast of Cheju Island, Korea. The structures of these metabolites were determined as KR025 and melithiazole F, previously reported bithiazoles, using combined spectroscopic methods. Both compounds showed an antifungal activity. In in vivo tests, these compounds exhibited potent controlling activities against tomato late blight, wheat leaf rust, and barley powdery mildew with control values more than 80% at a concentraton of 20 $\mu\textrm{g}$/ml.

Keywords

In vivo antifungal activity;KR025;melithiazole F;Myxococcus sp.;Myxobacteria

References

  1. Yamanaka, S., A. Kawaguchi, and K. Komagata. 1987. Isolation and identification of myxobacteria. J. Gen. Appl. Microbiol. 33: 247-265 https://doi.org/10.2323/jgam.33.247
  2. J. Gen. Appl. Microbiol. v.33 Isolation and identification of myxobacteria Yamanaka, S.;A. Kawaguchi;K. Komagata https://doi.org/10.2323/jgam.33.247
  3. TIBTECH v.6 Myxobacteria: a source of new antibiotics Reichenbach, H.;K. Gerth;H. Irschik;B. Kunze;G. Hosfle https://doi.org/10.1016/0167-7799(88)90100-X
  4. J. Antibiotics v.51 Cystothiazoles A and B, new bithiazole-type antibiotics from Cystobacter fulvus Ojika, M.;Y. Suzuki;A. Tsukamoto;Y. Sakagami;R. Fudou;T. Yoshimura;S. Yamanaka https://doi.org/10.7164/antibiotics.51.275
  5. J. Nat. Prod. v.62 KR025, a new cytotoxic compound from Myxococcus fulvus Ahn, J.-W.;S. -H. Woo;C. -O. Lee;K. -Y. Cho;B. S. Kim https://doi.org/10.1021/np9804233
  6. Angew. Chem. Int. Ed. Engl. v.36 Epothilones: Promising natural products with taxol-like activity Wessjohhann, L. https://doi.org/10.1002/anie.199707151
  7. Nature v.387 Cancer drugs better tan taxol? Cowden, C. J.;I. Paterson https://doi.org/10.1038/387238a0
  8. Canadian J. Microbiology v.15 Studies on the taxonomy of the Myxobacterales McCurdy, H. D. https://doi.org/10.1139/m69-259
  9. J. Antibiotics v.33 Myxothiazol, an antibiotic from Myxococcus fulvus Gerth, K.;H. Irschik;H. Reichenbach;W. Trowitzsch https://doi.org/10.7164/antibiotics.33.1474
  10. Kagakutoseibutsu v.27 Myxobacteria-Bacteria forming fruiting body Yamanaka, S.
  11. Drug discovery from nature Myxobacteria as producers of secondary metabolites Reichenbach, H.;G. Hoefle
  12. J. Antibiotics v.52 Melithiazoles, new β-methoxyacrylate inhibitors of the respiratory chain isolated from Myxobacteria Sasse, F.;B. Bohlendorf;M. Hermann;B. Kunze;E. Forche;H. Steinmetz;G. Hoefle;H. Reichenbach https://doi.org/10.7164/antibiotics.52.721