Isolation and Identification of Anticariotic Compound from Sophora flavescens Ait.

고삼으로부터 항우식활성 물질의 분리

  • 이현옥 (원광보건대학 치위생과) ;
  • 한동민 (원광대학교 자연과학기술학부) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2002.12.01

Abstract

The purpose of this study is to investigate anticariotic activity of the ethyl acetate soluble extract of Sophora flavescens Ait. for the prevention of dental caries and glucosyltransferase activity caused by Streptococcus mutans. The fraction 5-4-3 showed strong growth inhibition activity against Streptococcus mutans (MIC, 3.13 $\mu\textrm{g}$/ml). The glucosyltransferase activity of the active fraction 5-4-3 inhibited the formation of glucan and showed 77% of the antiproliferative effect at 100 $\mu\textrm{g}$/ml (P<0.05). Two flavanones, (2S)-2'-methoxy kurarinone (1) and (+)-kurarinone (2), were isolated from the active fraction 5-4-3 of the ethyl acetate soluble extract of S. flavescens Ait. Their structures were elucidated using spectroscopic methods.

Keywords

Streptococcus mutans;glucosyltransferase;Sophora flavescens Ait.;(2S)-2'-methoxykurarinone;(+)-kurarinone

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