Lowering Effects in Plasma Cholesterol and Body Weight by Mycelial Extracts of Two Mushrooms: Agaricus blazai and Lentinus edodes.

아가리쿠스와 표고버섯 균사체 추출물의 혈중롤레스테롤 및 체중감소 효과

  • 권미향 (고려대학교 생명공학원) ;
  • 권석태 (성균관대학교 유전공학과) ;
  • 권석형 (㈜렉스진바이오텍) ;
  • 마민숙 (㈜렉스진바이오텍) ;
  • 박영인 (고려대학교 생명공학원)
  • Published : 2002.12.01

Abstract

The effects of protein-bound polysaccharides (A-PBP and L-PBP) that were extracted from the mycelia of two edible mushrooms, namely Agaricus blazai and Lentinus edodes, on serum cholesterol and body weight were investigated in mice and female volunteers. Six groups of Male Balb/c mice were fed six kinds of diet supplement- solutions composed of L-PBP, A-PBP, chitosan, and other fiber constituents, for 30 days under the normal diet. Ninety female volunteers were also supplemented for 8 weeks with six kinds of capsules including control and five test groups as the same manners (two times a day, 4 capsules). From 12 days after feeding of L-PBP (Group I) and A-PBP (Group II), the weight of mice began to reduce as compared with control, whereas that of Group III fed chitosan was decreased 15 days after feeding. Group W and Group V which were fed mixture of L-PBP, A-PBP, chitosan, and other dietary fiber, were more significant in lowering weight. After 4 weeks of the supplementation in women, their serum LDL-cholesterol level and body weights in Group I and II were reduced, but Croup 111 taken with chitosan capsule showed weaker effect than Group I and II. After 8 weeks, LDL-cholesterol content in the sera of Group I (132.5 mg/dL) and II(131.5 mg/dL) was decreased to ideal level (125.4 and 122.8 mg/dL) for healthy blood vessel. In the case of Group W supplemented with mixture of L-PBP, A-PBP, and chitosan, the weight-reduction effect (11.8%) and hypocholesterolemic effect (11.0%) was most significant, indicating their synergistic action. These data suggested that the weight-controlling and hypolipidemic effect of L-PBP and A-PBP was involved, at least in part, in absorption of cholesterol as their role of dietary fiber, as well as cholesterol metabolism.

Keywords

Protein-bound polysaccharide;Agaricus blazai;Lentinus edodes;LDL-cholesterol;body weight

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