- Volume 15 Issue 3
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Effects of Refeeding with a Protein-Free Diets Supplemented with Various Essential Amino Acids on the Plasma Insulin-Like Growth Factor-I Concentration in Fasting Young Chickens
- Kita, K ;
- Shibata, T. ;
- Nagao, K. ;
- Hwangbo, J. ;
- Okumura, J.
- Received : 2001.08.13
- Accepted : 2001.11.23
- Published : 2002.03.01
The effect of refeeding with various single essential amino acids on the recovery of plasma insulin-like growth factor-I (IGF-I) concentration in fasted young chickens was examined. Young chickens (29 days of age) were divided into 15 experimental groups. Chickens in one group were fed on the commercial diet ad libitum for 4 days. The remaining 56 chickens in 14 experimental groups were fasted. After 2 days of fasting, 52 chicks in 13 fasted groups were refed with one of the following experimental diets for 2 days. Eleven experimental diets were protein-free diets supplemented with one of 11 essential amino acids (Arg, Gly, His, Ileu, Leu, Met, Phe, Lys, Thr, Trp, Val). The remaining 2 experimental diets were a protein-free diet containing 11 essential amino acids and a protein-free diet not supplemented with amino acids. Birds in the remaining fasted group continued to be fasted for 2 days. Fasting for 2 days markedly reduced plasma IGF-I concentration. When fasted chickens were refed the protein-free diet containing either Gly alone or all essential amino acids, plasma IGF-I concentration was recovered to the level similar to that of fed chickens. Protein-free diet alone, however, failed to restore the reduced IGF-I concentration in plasma. Body weight loss modulated by feeding with protein-free diets supplemented with various single essential amino acids was associated with changes in plasma IGF-I concentrations. We concluded that body weight loss by feeding with a protein-free diet was lower than that of fasted chickens and that body weight loss associated with the decrease in plasma IGF-I concentration was modulated by feeding with protein-free diets containing various single essential amino acids.
Essential Amino Acid;Fasting;Refeeding;Insulin-Like Growth Factor-I;Chickens
- Kita, K., S. Matsunami and J. Okumura. 1996a. Relationship of protein synthesis to mRNA levels in the liver of chicks under various nutritional conditions. J. Nutr. 126:1610-1617.
- Kita, K. and J. Okumura. 1999. Dietary protein levels alter plasma insulin-like growth factor-I concentration of chicks. Jpn. Poult. Sci. 36:25-30. https://doi.org/10.2141/jpsa.36.25
- Kita, K., F. M. Tomas, P. C. Owens, S. E. Knowles, B. E. Forbes, Z. Upton, R. Hughes and F. J. Ballard. 1996b. Influence of nutrition on hepatic IGF-I mRNA levels and plasma concentrations of IGF-I and IGF-II in meat-type chickens. J. Endocrinol. 149:181-190. https://doi.org/10.1677/joe.0.1490181
- Muramatsu, T., M. Kato, I. Tasaki and J. Okumura. 1986. Enhanced whole-body protein synthesis by methionine and arginine supplementation in protein-starved chicks. Br. J. Nutr. 55:635-641. https://doi.org/10.1079/BJN19860069
- National Research Council. 1984. Nutrient Requirements of Poultry, 8th Rev. Ed. National Academy Press, Washington, DC., USA.
- Read, L. C., F. J. Ballard, G. L. Francis, R. C. Baxter, C. J. Bagley and J. C. Wallace. 1986. Comparative binding of bovine, human and rat insulin-like growth factors to membrane receptors and to antibodies against human insulin-like growth factor-I. Biochem. J. 233:215-221. https://doi.org/10.1042/bj2330215
- Takenaka, A., N. Oki, S. Takahashi and T. Noguchi. 2000. Dietary restriction of single essential amino acids reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGF-binding protein-1 in rats. J. Nutr. 130:2910-2914.
- Rosebrough, R. W., A. D. Mitchell and J. P. McMurtry. 1996. Dietary crude protein changes rapidly alter metabolism and plasma insulin-like growth factor I concentrations in broiler chickens. J. Nutr. 126:2888-2898.
- Rosebrough, R. W. and J. P. McMurtry. 1993. Protein and energy relationships in the broiler chicken. 11. Effects of protein quantity and quality on metabolism. Br. J. Nutr. 70:667-678. https://doi.org/10.1079/BJN19930162
- Ballard, F. J., R. J. Johnson, P. C. Owens, G. L. Francis, F. M. Upton, J. P. McMurtry and J. C. Wallace. 1990. Chicken insulin-like growth factor-I: amino acid sequence, radioimmunoassay, and plasma levels between strains and during growth. Endocrinology. 79:459-468. https://doi.org/10.1016/0016-6480(90)90076-X
- Furuse, M., Y. H. Choi, S. I. Yang, K. Kita and J. Okumura. 1991. Enhanced release of cholecystokinin in chickens fed diets high in phenylalanine or tyrosine. Comp. Biochem. Physiol. 99A:449-451. https://doi.org/10.1016/0300-9629(91)90031-7
- Rosebrough, R. W., J. P. McMurtry and R. Vasilatos-Younken. 1992b. Metabolic and hormonal effects of feeding chickens thyroxine and diets containing varied calorie to protein ratios. Nutr. Res. 12:77-87. https://doi.org/10.1016/S0271-5317(05)80411-7
- Duncan, D. B. 1955. Multiple range and multiple F test. Biometrics. 11:1-42. https://doi.org/10.2307/3001478
- Okumura, J., K. Yamaguchi and M. Yanaka. 1980. Growth and utilization of dietary nitrogen and energy in chicks fed excess phenylalanine or tyrosine diets. Jpn. Poult. Sci. 17:256-264. https://doi.org/10.2141/jpsa.17.256
- Rosebrough, R. W., J. P. McMurtry and R. Vasilatos-Younken. 1992a. In vitro lipid metabolism, growth and metabolic hormone concentrations in hyperthyroid chickens. Br. J. Nutr. 68:667-676. https://doi.org/10.1079/BJN19920124
- Kita, K., K. Nagao, N. Taneda, Y. Inagaki, K. Hirano, T. Shibata, M. Aman Yaman, M. A. Conlon and J. Okumura. 2002. Insulin-like growth factor binding protein-2 gene expression can be regulated by diet manipulation in several tissues of young chickens. J. Nutr. (In press).