Comparisons of Renoprotective Activities between White Ginseng Radix and Rootlet in Spontaneously Hypertensive Rats with Diabetes

  • Published : 2002.02.21


The renoprotective activities of white ginseng radix and rootlet were compared in spontaneously hypertensive rat (SHR) with diabetes. During oral administration of white ginseng radix (Ginseng Radix Alba, GRA) and white ginseng rootlet (Ginseng Radix Palva, GRP) for four weeks, arterial blood pressure and blood glucose levels were determined at every 10 days. In both GRA- and GRP-treatment groups, arterial blood pressures started to go down after 10 days of administration and maintained throughout the study period. After four weeks administrations of GRA and GRP, diastolic blood pressures were significantly decreased with 17% and 9%, respectively. GRA treatment also decreased blood glucose levels after 10 days of administration when compared with diabetic SHR group. At the end of the experiment, serum creatinine (Scr) and blood urea nitrogen (BUN) were not significantly different between the groups, except 62% higher value of BUN in diabetic SHR group when compared with SHR group. In the diabetic SHR group, the excretion of urinary albumin was increased significantly when compared with SHR. The level of urinary albumin in GRA treated group was markedly reduced when compared with diabetic SHR group $(67.8{\pm}4.7\;vs.\;131.3{\pm}13.5\;mg/24\;h).$ To examine the effects of ginseng radices on an overt diabetic nephropathy, index of kidney hypertrophy and transforming growth $factor-{\beta}1\;(TGF-{\beta}1)$ protein levels were evaluated. The glomerular and tubular cells stained positive for $TGF-{\beta}1$ seemed to be more abundant in diabetic SHR than in those with SHR, and GRA treated rats showed somewhat less $TGF-{\beta}1$ protein in glomerular and tubular cells when compared with diabetic SHR. Our results suggest that GRA might be a useful antihypertensive and antidiabetic agent with renoprotective effect.


  1. Han KH, Choe SC, Kim HS, Shon DW, Nam KY, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW. Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chi Med 26: 199-209, 1998
  2. Krege J.H, Hodgin JB, Hagaman JR, Smithies O. A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension 25: 1111-1115, 1995
  3. Cooper PK, Navar LG. Disparate effects of Ca channel blockade on afferent and efferent arteriolar responses to ANGO II. Am J Physiol 256: F1015-FI020, 1989
  4. Verhoeven NM, Guerand WS, Struys EA, Bouman AA, van der Knaap MS, Jakobs C Plasma creatinine assessment in creatine deficiency: A diagnostic pitfall. J Inherit Metab Dis 23(8): 835-840, 2000
  5. Wilson GL, Letter EH. Streptozotocin interactions with pancreatic beta cells and the induction of insulin-dependent diabetes. Curr Top Microbiol Immww 156: 27-54, 1990
  6. Flyvbjerg A. Marshall SM, Frystyk J, Hansen KW, Harris AG, Orskov H. Octreotide administration in diabetic rats: effect on renal hypertrophy and urinary albumin excretion. Kidney Int 41:805-812, 1992
  7. Chung SH, Choi CG, Park SH. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanisms in KKAy mice. Arch Phar Res 24: 214-218, 2001
  8. Vuksan V, Leiter L, Stavro MP, Josse RG, Sievenpiper JL, Xu Z, Beljan-Zdravkovic D. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 23: 1221-1226, 2000
  9. Flyvbjerg A. Role of the growth hormone, insulin-like growth factors (IGFs) and IGF-binding proteins in the renal complications of diabetes. Kidney Int 52: S12-S19, 1997
  10. Sonnenborn D, Proppert,Y. Ginseng (Panax ginseng C.A. Meyer). Zeitschrift fur Phytotherapie 11: 35-49, 1990
  11. Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in noninsulin-dependent diabetic patients. Diabetes Care 18(10): 1373-1375, 1995
  12. Lawrence DA. Transforming growth factor-$\beta$: an overview. Kidney Int 47: SI9-S23, 1995
  13. Trinder T. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Annal Clin Biochem 6: 24-28, 1069
  14. Zhang G, Ichimura T, Wallin A, Kan M, Stevens JL. Regulation of the rat proximal tubule epithelial cell growth factors, insulin-like growth factor I, transforming growth factor-$\beta$ and analysis offibroblast growth factors in rat kidney. J Physiol 148: 295-305, 1991
  15. Hallstrom C, Fulder S, Carruthers M. Effects of ginseng on the performance of nurses on night duty. Com.parative Medicine East and West 6: 277-282, 1982