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Synthesis and Some Reactions of New Thieno[2,3-c]pyridazine Derivatives

  • Bakhite, Etify A. ;
  • Mohamed, Omima S. ;
  • Radwan, Shaban M.
  • Published : 2002.12.20

Abstract

Treatment of ethyl 5-hydroxy-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate (1a) with hydrazine hydrate in ethanol gave the carbohydrazide 2,. Some derivatives of the latter compound have been synthesized. Also, 6-acetyl-3,4-diphenyl-5-hydroxythieno[2.3-c]pyridazine (1b) was subjected to some reactions to produce other new thienopyridazine derivatives.

Keywords

Thienopyridazines;Pyranothienopyridazines;Pyrazoline;Oxadiazole

References

  1. Abbady, M. S.; Radwan, Sh. M. Phosphorus, Sulfur and Silicon 1994, 86, 203. https://doi.org/10.1080/10426509408018405
  2. Radwan, Sh. M. Phosphorus, Sulfur and Silicon 2000, 165, 155. https://doi.org/10.1080/10426500008076334
  3. Radwan, Sh. M. Phosphorus, Sulfur and Silicon 1999, 155, 175. https://doi.org/10.1080/10426509908044981
  4. Radwan, Sh. M.; Bakhite, E. A. Montash Chem. 1999, 199, 1117.
  5. Radwan, Sh. M.; Abbady, M. S.; El-Kashef, H. S. Phosphorus, Sulfur and Silicon 1994, 89, 193. https://doi.org/10.1080/10426509408020449
  6. Andersen, H. S.; Branner, S.; Jeppensen, C. B.; Moller, N. P. H.; Surhav, S.; Mjalli, A. PCT. Int. APP. WO, 9915, 529; C.A. 1999, 130, 267445 g.
  7. Iwase, N.; Ooshmia, M. Jpn. Kokai Tokkyo Koho JP 07 33, 773 [95, 33, 775]; C. A. 1995, 122, 290874 g.
  8. Kawano, M. Y.; Shimaza, H.; Ashida, Y.; Miyake, A. Chem. Pharm. Bull. 1996, 44, 122. https://doi.org/10.1248/cpb.44.122
  9. Radwan, Sh. M.; Bakhite, E. A.; Kamal El-Dean, A. M. Bull. Fac. Sci. (Assiut Unvi.) 1994, 23, 1.
  10. Lurashi, E.; Arena, F.; Sacchi, A.; Lanemi, S.; Abignente, E.; Amico, M. D.; Berrino, L.; Rossi, F. Farmaco 1995, 50, 439.

Cited by

  1. Design and synthesis of some thieno[2,3-c]pyridazine derivatives of expected anticancer activity vol.22, pp.6, 2013, https://doi.org/10.1007/s00044-012-0258-9