Protective Effects of Paeonia japonica against Radiation-induced Damage

방사선 장해에 대한 백작약의 방호효과

  • Oh, Heon (Radiation Food Technology and Bioscience team, Korea Atomic Energy Research Institute) ;
  • Park, Hae-Ran (Radiation Food Technology and Bioscience team, Korea Atomic Energy Research Institute) ;
  • Jeong, Ill-Yun (Radiation Food Technology and Bioscience team, Korea Atomic Energy Research Institute) ;
  • Kim, Sung-Ho (College of Veterinary medicine, Chonnam National University) ;
  • Jo, Sung-Kee (Radiation Food Technology and Bioscience team, Korea Atomic Energy Research Institute)
  • 오헌 (한국원자력연구소 방사선식품 생명공학기술 개발팀) ;
  • 박혜란 (한국원자력연구소 방사선식품 생명공학기술 개발팀) ;
  • 정일윤 (한국원자력연구소 방사선식품 생명공학기술 개발팀) ;
  • 김성호 (전남대학교 수의과대학) ;
  • 조성기 (한국원자력연구소 방사선식품 생명공학기술 개발팀)
  • Published : 2002.09.30

Abstract

We investigated the effect of Paeonia japonica (PJ) on radiation-induced oxidative damage to macromolecules in vitro and in vivo. The PJ reduced the tail moment (TM) which was a marker of DNA strand break in single-cell gel electrophoresis (SCGE; comet assay) in the human peripheral blood lymphocytes. Lipid peroxidation in the liver of the ICR mouse, measured as malondialdehyde (MDA), was also reduced by PJ administration. Ethanol fraction of PJ was more effective than polysaccharide fraction of that on reduction of TM in SCGE and lipid peroxidation. Also, Their activities to scavenge DPPH radicals and hydroxyl radicals were observed in vitro, and the activities were due to its ethanol fraction. It is plausible that scavenging of flee radicals by PJ extract may have played an important role in providing the protection against the radiation-induced damage. These results indicated that Paeonia japonica might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

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