Determination of Mefenamic Acid with Fe(II)-Dipyridyl-Mefenamic Acid Ternary Complex as Ion-exchagner

철-디피리딜-메페남산 삼원착물을 이용한 메페남산의 정량

  • Nam, Su Ja (Department of Pharmacy, Kyungsung University) ;
  • Moon, Hyun Sook (Department of Pharmacy, Kyungsung University) ;
  • Lee, Mi Na (Department of Pharmacy, Kyungsung University) ;
  • Jung, Moon Mo (Department of Pharmacy, Kyungsung University) ;
  • Hur, Moon Hye (Pusan Regional Food & Drug Administration) ;
  • Ahn, Moon Kyu (Department of Pharmacy, Kyungsung University)
  • Received : 2000.12.21
  • Published : 2001.02.25

Abstract

A PVC membrane electrodes based on Fe(II)-dipyridyl-mefenamic acid ternary complex as ion exchanger were prepared using o-nitrophenyl octyl ether as a plasticizer. The 2,2'-dipyridyl, 4,4'-dipyridyl and 4,4'-dipyridyl-2,2'-dipyridyl were used as dipyridyl derivative ligand. The electrode dxhibits a fast stable and linear response for $10^{-5}-10^{-3}mol/L$ mefenamate with an anionic slope of -55.98, -49.47, -59.35mV/decade in pH 8.9 borate buffer solution respectively. Potentiometric selectivity measurements revealed negligible interferences from aromatic and aliphatic carboxylic acid salts.

Keywords

dipyridyl;ternary complex;mefenamic acid

Acknowledgement

Supported by : 경성대학교

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