Acute toxicity response caused by mixture or tank mix of several insecticides

몇 가지 살충제의 혼용 및 혼합 시 독성반응

  • 이제봉 (농업과학기술원 농약안전성과) ;
  • 정미혜 (농업과학기술원 농약안전성과) ;
  • 성하정 (농업과학기술원 농약안전성과) ;
  • 이해근 (농업과학기술원 농약안전성과) ;
  • 양재설 (농업과학기술원 농약안전성과)
  • Published : 2001.12.31

Abstract

Tank mixing application of pesticides has been used to reduce labor and to control wide spectrum of pests, but it may cause significant pesticide poisoning on human and animals due to carelessness. The toxic response of pesticides for the tank mixtures and mixtures was investigated to determine acute toxicity and enzymatic change using experimental animals. Acute oral toxicity and acute dermal toxicity were tested by RDA test guideline. The $LD_{50}$ was calculated by probit analysis method and cholinesterase was measured with automatic analyzer. The toxicities were generally higher than estimated toxicities in tank mixing and mixture. Serum cholinesterase activity was inhibited more than expected at the dose levels of 1/5, 1/10 and 1/20 of $LD_{50}$. Therefore, the results of this study showed that acute toxicity caused by the pesticide mixtures should be considered before the tank mixing method is applied.

Keywords

toxicity response;tank mixing;cholinesterase activity