The Effect of Long-term Administration of Excessive Amount of Garlic on Hematology in HK Phenotype Jindo-Dog

장기간 과량의 마늘투여가 HK phenotype 진도견의 혈액상에 미치는 영향

  • Published : 2001.09.01


The garlic has been eaten widely regardless of easten and westen countries to cure the various disease like cancer, tuberculosis, dentalgia, toxemia and leprosy from ancient times. Even now it is reported that they lower the level of triglycerides and cholesterol in blood and that they also affect on the cohesive power of the platelets. In addition, it is also known that it lowers the glucose level in blood. Especially, the sulfur containing amine acid and the derivatives of the garlic has the counteracting effect to heavy metals. Nowadays, the garlic is known for its efficiency for the various kinds of cancer, neoplasms, hypertension, arteriosclerosis and apoplexy. However, it is reported that the intake of the excessive amount of garlic causes hemolytic anemia recently. The hemolytic anemia is more severe especially in HK phenotype dogs which has Na-K-ATPase activity. Therefore, this study was performed to examine the effect on the blood of the HK phenotype Jindo dogs when administered the excessive amount of garlic. HK phenotype group showed the significant decrease on RBC, WBC, PCV, Hb, MCV, MCHC, GSH, Met-Hb but LK phenotype group didn's show the significant decrease. AST, ALT, BUN, creatinine, CPK, glucose, and total protein values were within normal ranges during the period.


  1. Vet Med v.135 Normal blood values in the beagle Anderson AC;Gee W
  2. J Lab Clin Med v.61 Improved method for the determination of blood glutathione Beutler E;Duron O;Kelly BM
  3. A manual of biochemial methods(3rd ed.) Red blood cell metabolism Beutler E
  4. Br J Haematol v.30 Activated oxygen and hemolysis Carrell RW;Winterbourn CC;Rachmiewitz EA
  5. Biochim Biophys Actab v.79 Species differences in the effect of sodium Chan PC;Calabrese V;Theil LS
  6. J Am Vet Med Assoc v.190 Pseudohyperkalemia in akitas Degen M
  7. J Am Anim Hosp Assoc v.10 Hemolytic anemia due to ingestion of onions in a dog Farkas MC;Farkas JN
  8. Crit Rev Food Sci Nutr v.22 The genus allium part 1 Fenwick GR;Hanley AB
  9. Experimental Animal v.46 Heredity of red blood cells with high K and low glutathione(HK/LG) and high glutathione(HK/HG) in a family of japanese shiba dogs Fujise H;Hishiyama N;Ochiai H
  10. J Am Med Sci v.181 Anemia in dogs produced by feeding of the whole onions and of onion products Gruhzit OM
  11. Vet Patho v.22 Experimental onion-induced hemolytic anemia in dogs Harvey JW;Rackear D
  12. J Can Vet v.18 Onions as a cause of heinz body anemia and death in cattle Hutchison TWS
  13. Feline Pract v.11 Onion poisoning in the cat Kobayshi K
  14. J Am Anim Hosp Assoc v.15 Idiopathic heinz body hemolytic anemia in three dogs Lees GE;Polzin DJ;Perman V;Hammer RF;Smith JA
  15. J Am Vet Med Assoc v.200 Hematologic effects and feeding performance in cattle fed cull domestic onions Lincoln SD;Howell ME;Combs JJ;Himman DD
  16. J Am Vet Res v.48 no.1 Energy metabolism in canine erythrocytes associated with inherited high$Na^{+}-and\;K^+$-stimulated adenosine triphosphatase activity Maede Y;Inaba M
  17. Blood v.61 Increase of Na-K-ATPase activity, glutamate and aspartate uptake in dog erythrocytes ssociated with hereditary high accumulation of GSH, glutamate, glutamine and aspatate Maeda Y;Inada M;Taniguchi N
  18. Res Vet Sci v.50 Hereditary high-potassium erythrocytes with high Na, K-ATPase activity in japanese shiba dogs Maede Y;Amano Y;Nishida A;Murase T;Sasaki A;Inaba M
  19. Jap J Vet Sci v.39 High concentration of blood glutathione in dogs with scute hemolytic anemia Maede Y
  20. St Marianna Med J v.8 Microdetermination of methemoglobin and the normal value Nakamura I;Nishid N;Maruyama H;Kudo Y;Kagami M
  21. Experimantal Animal v.37 Adog possessing high glutathione(GSH) and K concentrations with an increased Na, K-ATPase activity in its erythrocytes Ogawa E;Fujise H;Kobayashi K
  22. J Am Vet Med Assoc v.160 Acute hemolytic anemia caused by wild onion poisoning in horses Pierce KR;Joyce JR;England RB;Jones LP
  23. Jpn J Vet Sci v.48 no.4 Effect of onion ingestion on anti-oxidizing agents in dog erythrocytes Ogawa E;Shinoki T;Akahori F;Msaoka T
  24. Public Health Rep v.45 An anemia in dogs produced by feedig onions Sebrell WH
  25. J Can Vet v.17 Hemolytic anemia associated with ingestion of onions in a dog Spice RN
  26. Vet Rec v.108 Onion poisoning in a dog Stallbaumer M
  27. J Am Vet Med Assoc v.156 Hemolytic anemia in sheep fed wild onions Van Kampen KR;James LF;Johnson AE
  28. Vet Rec v.117 Van den Ingh T.S.G.A.M. Onion poisoning of young cattle Verhoff J;Hajer R
  29. Pharmac Ther v.47 Glutathione-dependent protection anainst oxidative injury Xiaoqin Shan;Tak Yee Aw;Dean P Jones
  30. Biochim Biophy Acta v.1427 Reduced glutathione accelerates the oxidative damage produced by sodium n-propyl thiosulfate, one of the causative agents of onion-induced hemilytic anemia in dogs Yamato O;Hayashi M;Kasai E;Tajima M;Yamasaki M;Maede Y
  31. 한국영양학회지 v.30 no.2 고 또는 저콜레스테롤 식이를 먹인 쥐에 있어서 양파, 마늘이 체내 콜레스테롤과 중성지방 수준 및 혈소판 응집에 미치는 영향 강정애;강정숙
  32. 한국유화학회지 v.8 no.2 마늘이 콜레스테롤 식이를 투여한 흰쥐의 혈청성분에 미치는 영향 김만수;김송전;이인실
  33. 한국식품과학회지 v.24 no.4 가열매체 및 증발온도가 마늘즙의 농축에 미치는 영향 김병삼;박노현;박무현;한봉호
  34. 한국영양식량학회지 v.24 no.6 장시간 운동시 마늘섭취가 항피로 및 피로회복에 미치는 영향 백영호
  35. 한국영양식량학회지 v.23 no.6 마늘즙 투여가 흰쥐의 수은독성에 미치는 영향 서화중;김영수;김경수;정두례
  36. 한국식품영양과학회지 v.26 no.1 처리법을 달리한 마늘첨가식이가 자발성 고혈압쥐의 혈액에 미치는 영향 전희정;백재은
  37. 한국농화학회지 v.40 no.6 마늘과 생강의 항균성 및 증류성분 지원대;정민선;정현채;이숙정;정영건
  38. 한국영양식량학회지 v.19 no.5 마늘성분에 의한 면역증강 및 항암효과 황우익;이성동;손홍수;백나경;지유환