The Role of CpG DNA in Immunostimulation and Therapeutic Application

  • 이경미 (바이오세인트(주) 환경생명공학연구소)
  • Published : 2001.12.01




  1. Adv. Immunol. v.73 Bacterial CpG DNA activates immune cells to signal infectious danger H. Wagner
  2. J. Immunol. v.160 Modulation of airway inflammation by CpG oligonucleotides in a murine model of asthma J. N. Kline;T. R. Businga;T. J. Waldschmidt;J. V. Weinstock;A. M. Kreig
  3. Curr. Opin. Immunol. v.12 The role of CpG motifs in innate immunity A. M. Kreig
  4. Trends Microbiol. v.6 Bcaterial DNA as immune cell activator G. B. Lipford;K. Heeg;H. Wagner
  5. Nature v.374 CpG motifs in bacterial DNA trigger direct B-cell activation A. K. Kreig;A. K. Yi;S. matson;T. J. Waldschmidt;G. A. Bishop;R. Teasdale;G. Koretzky;D. Klinman
  6. J. Immunol. v.164 Mechanism and function of a newly identified CpG DNA motif in human primary B cell G. Hartmann;A. M. Kreig
  7. Proc. Natl. Acad. Sci. USA v.96 CpG DNA;a potent signal for growth, activation, and maturation of human dendritic cells G. Hartmann;G. J. Weiner;A. M. Kreig
  8. Adv. Drug Del. Rev. v.44 The role of CpG motifs in immunomodulation and gene therapy R. K. Scheule
  9. Biochem. Biophys. Acta 93321 Mechnim and applications of immune stimulatory CpG oligodeoxynucleotides A. M. Kreig
  10. Eur. J. Immunol. v.27 Immunostimulatory DNA;sequence dependent production of potentially harmful or useful cytokines G. B. Lipford;T. Sparawasser;M. Bauer;S. Zimmermann;e. S. Koch;K. Heeg;H. Wager
  11. Trends Immunolo. v.16 CpG DNA;a novel adjuvant for systemic and mucosal immunization with influenza virus Z. Moldoveanu;L. Love-Homan;W. Q. Huang;A. M. Kreig
  12. Nature Med. v.3 Immunostimulatory DNA sequences function as T helper-a-promoting adjuvants M. Roman;E. Martin-Orozco;J. S. Goodman;M. D. Nguyen;Y. Sato;A. Ronaghy;R. S. Kornbluth;D. D. Richman;D. A. Carson;E. Raz
  13. Cell Immunol. v.191 Immunostimulatory DNA in a potent mucosal adjuvant A. A. Horner;a. Ronaghy;P. M. Cheng;M. D. Nguyen;H. J. Cho;D. Broide;E. Raz
  14. J. Immunol. v.162 Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides S. Sur;J. S. Wild;B. K. Choudhury;N. Sur;R. Alam;D. M. Klinmann
  15. Proc. Natl. Acad. Sci. USA v.95 Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs A. M. Kreig;T. Wu;R. Weeratna;S. M. Efler;L. Love-Homan;L. Zhang;L .Yang;A. K. Yi;D. Short;H. Davis
  16. Antisense Nucl. Acid Drug Devl. v.9 Lack of immune stimulation by immobilized CpG-oligonucleotide L. Manzel;D. E. Macfarlane
  17. J. Immunol. v.163 CpG oligonucleotides downregulate marcrophge class Ⅱ MHC antigen processing R. S. Chu;D. Askew;E. H. Noss;A. Tobian;A. M. Kreig;C. V. harding
  18. Gene Ther. v.6 CpG DNA and LPS induce distinct patterns of activation in human monocytes G. Hartmann;A. M. Kreig
  19. J. Exp. Med. v.189 DNA vaccination;transfection and activation of dendritic cells as key events for immunity O. Akabari;N. Panjwani;S. Garcia;R. Tascon;D. Lowrie;B. Stockinger
  20. Nature Immunol. v.2 CpG DNA;security code for host defense R. Medzhitov
  21. Trends Immunol. v.22 Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice T. Kaisho;s. Akira
  22. Immunity v.14 Toll meets bacterial CpG-DNA W. Hermann
  23. Cell v.103 DNA-PKcs is required for activation of innate immunity by immunstimulatory DNA W. M. Chu;X. Gong;Z. W. Li;K. Takabayashi;H. H. Chen;A. Lois;D. J. Chen;G. C. Li;M. Karin;E. Raz