A Feasibility Study of the IMRT Optimization with Pseudo-Biologic Objective Function

유사생물학적 대상 함수를 이용한 IMRT 최적화 알고리즘 가능성에 관한 연구

  • Yi, Byong-Yong (Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Cho, Sam-Ju (Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Ahn, Seung-Do (Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Kim, Jong-Hoon (Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Choi, Eun-Kyung (Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Chang, Hye-Sook (Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Kwon, Soo-Il (Dept. of Medical Physics Kyonggj University)
  • 이병용 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
  • 조삼주 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
  • 안승도 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
  • 김종훈 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
  • 최은경 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
  • 장혜숙 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
  • 권수일 (경기대학교 대학원 의학물리학과)
  • Published : 2001.12.30

Abstract

The pseudo-biologic objective function has been designed for the IMRT optimization. The RTP Tool Box (RTB) was used for this study. The pseudo-biologic function is similar to the biological objective function in mathematical shape, but uses physical parameters. The concepts of the TCI (Target Coverage Index) and the OSI (Organ Score Index) have been introduced for the target and the normal organs, respectively. The pseudo-biologic objective function s has been defined using these TCI and OSI's. The OSI's from the pseudo-biological function showed better results than from the physical functions, while TCI's showed similar tendency. These results revealed the feasibility of the pseudo-biologic function as an IMRT objective function.