The effects of herbs on the radiation-induced apoptosis in intestinal crypt cells

방사선 조사 마우스에서 소장움세포의 Apoptosis 발생에 미치는 생약의 효과

  • Kim, Sung-Ho (College of veterinary Medicine, Chonnam National University) ;
  • An, Mi-Ra (College of veterinary Medicine, Chonnam National University) ;
  • Nah, Seung-Yeol (College of veterinary Medicine, Chonnam National University) ;
  • Lee, Jong-Hwan (College of veterinary Medicine, Chonnam National University) ;
  • Kim, Jae-Ha (College of Medicine, Chonnam National University) ;
  • Jo, Sung-Kee (Food. Irradiation Team, Korea Atomic Energy Research Institute) ;
  • Jang, Jong-Sik (Dept. of Animal Science, Sangju National University) ;
  • Shin, Dong-Ho (College of veterinary Medicine, Chonnam National University)
  • 김성호 (전남대학교 수의과대학) ;
  • 안미라 (전남대학교 수의과대학) ;
  • 나승렬 (전남대학교 수의과대학) ;
  • 이종환 (전남대학교 수의과대학) ;
  • 김재하 (전남대학교 의과대학) ;
  • 조성기 (한국원자력연구소 방사선식품 생명공학기술개발팀) ;
  • 장종식 (상주대학교 축산학과) ;
  • 신동호 (전남대학교 수의과대학)
  • Published : 2001.03.31

Abstract

This study was performed to determine the effect of several herbs on radiation-induced apoptosis in jejunal crypt cells. Longyanrou(Euphoris longana), Suanzaoren(Zizyphus vulgaris), Yuanzhi(Polygala tenuifolia), Rensan(Panax ginseng), Fuling(Poria cocos), Muxiang (Saussurea lappa), Chuanxiong(Cnidium officinale), Baishaoyao(Paeonia lactifolia), Shengma (Cimicifuga heracleifolia), Chaihu (Bupleurum falcatum) and Dongchongxiacao ( Paecilomyces japonica) reduced the frequency of radiation-induced apoptosis(p<0.05). Although the mechanisms of this effect remain to be elucidated, these results indicated that Longyanrou, Suanzaoren, Yuanzhi, Rensan, Fuling, Muxiang, Chuanxiong, Baishaoyao, Shengma, Chaihu and Dongchongxiacao might be useful inhibitors of apoptosis, especially since these are relative nontoxic natural products.