The Radioprotective Effects of Rhizomata Herbs

대표적 근경류 생약의 방사선 방호효과

  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Jo, Sung-Kee (Food Irradiation Team, KAERI) ;
  • Kwon, Oh-Deog (College of Veterinary Medicine, Chonbuk National University)
  • 김성호 (전남대학교 수의과대학) ;
  • 조성기 (한국 원자력연구소 방사선 식품공학팀) ;
  • 권오덕 (전북대학교 수의과대학)
  • Published : 2001.03.31

Abstract

We performed this study to determine the effect of Baizhu (Atractylodes japonica), Chuanxiong (Cnidium officinale), Shanyao (Discorea japonica) and Shengma (Cimicifuga heracleifolia), as Oriental rhizomata herbs, on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of ${\gamma}$-radiation. Shengma was effective in intestinal crypt survival(p<0.05). The frequency of radiation induced apoptosis was also reduced by pretreatment with Chuanxiong and Shengma(p<0.05). Although the mechanisms of this effort remain to be elucidated, these results indicated that Shengma might be a useful radioprotector, especially since it is a relatively nontoxic natural product.