Multiple Xanthomatosis in Familiar Hypercholesterolemia Patient - A case report -

가족성 고콜레스테롤혈증 환자에서의 다발성 황색종 - 1례 보고 -

  • Rhee, Seung-Koo (Department of Orthopedic Surgery, St. Mary Hospital, College of Medicine, Catholic University of Korea) ;
  • Lee, Hwa-Sung (Department of Orthopedic Surgery, St. Mary Hospital, College of Medicine, Catholic University of Korea) ;
  • Moon, Chan-Woong (Department of Orthopedic Surgery, St. Mary Hospital, College of Medicine, Catholic University of Korea)
  • 이승구 (가톨릭대학교 의과대학 성모병원 정형외과학교실) ;
  • 이화성 (가톨릭대학교 의과대학 성모병원 정형외과학교실) ;
  • 문찬웅 (가톨릭대학교 의과대학 성모병원 정형외과학교실)
  • Published : 2000.03.30

Abstract

We experienced the case of familiar hypercholesterolemia with multiple xanthomas which was treated by combined surgical and medical therapy. He was 26-year-old male patient of familiar hypercholesterolemia with multiple xanthomas in 22 sites on whole body, and was treated by 17 surgical excisions of the xanthomas and by medical therapy of the hypercholesterolemia. There was a normal healing process of the surgical wounds. Continual postoperative medical therapy of the hypercholesterolemia was done. There was no recurrence of the symptoms during more than 13 months of follow-up. But the serum level of the cholesterol was not lowered significantly, so we are treating him with drug therapy. Familial hypercholesterolemia is caused by a specific disorder of lipid metabolism, and is characterized by increased LDL cholesterol, tendon xanthomas, coronary disease associated with autosomal dominant transmission. Xanthomas usually appear in the second decade of life with familiar hypercholesterolemia which may have high risk for premature coronary atherosclerosis, which might be prevented with early diagnosis and medical treatment. So, orthopedic surgeons do not only excise the xanthomatosis surgically but also can diagnose the underlying hypercholesterolemia.